Abstract
In a prospective, randomised, masked trial, 91 patients undergoing intraocular surgery received an anaesthetic mixture containing lignocaine hydrochloride 2% and bupivacaine hydrochloride 0.5%. In addition group 1 had hyaluronidase (50 i.u./ml) and adrenaline (1:200,000), group 2 had hyaluronidase alone, group 3 had adrenaline alone and group 4 had neither. The groups were compared regarding the quality of operating conditions. Hyluronidase had a substantial beneficial effect though there was no significant difference related to the use of adrenaline. Anaesthesia was less effective in patients under the age of 65 years.
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References
Weis JL and Deichman CB : A comparison of retrobulbar and periocular anaesthesia for cataract surgery. Arch Ophthalmol 1989, 107: 96–8.
Whitsett JC, Balyeat HD, McClure B : Comparison of one-injection-site peribulbar anaesthesia and retrobulbar anaesthesia. J Cataract Refract Surg 1990, 16: 243–45.
Hamilton RC, Gimbel HV, Strunin L : Regional anaesthesia for 12,000 cataract extraction and intraocular lens implantation procedures. Can J Anaesth 1988, 35: 615–23.
Wang HS : Peribulbar anaesthesia for ophthalmic procedures. J Cataract Refract Surg 1988, 14: 441–3.
Mindel JS : Value of hyaluronidase in ocular surgical akinesia. Am J Ophthalmol 1978, 85: 643–6.
Nicol JMV, Treuren B, Acharya PA, et al.: Retrobulbar anaesthesia: the role of hyaluronidase. Anaesth Analg 1986, 65: 1324–8.
Thomson I : Addition of hyaluronidase to lignocaine with adrenaline for retrobulbar anaesthesia in the surgery of senile cataract. Br J Ophthalmol 1988, 72: 700–2.
House PH, Hollands RH, Schulzer M : Choice of anaesthetic agents for peribulbar anaesthesia. J Cataract Refract Surg 1991, 17: 80–3.
Fry RA and Henderson J : Local anaesthesia for eye surgery. Anaesthesia 1989, 45: 14–17.
Johnson DE and Gills JP : Advanced ophthalmic anaesthesia. In Spaeth G, Katz LJ (eds): Current therapy in ophthalmic surgery. BC Becker, Toronto, 1989, 1–5.
Zahl K, Jordan A, McGroarty J, et al.: Peribulbar anaesthesia. Effect of bicarbonate on mixtures of lignocaine, bupivacaine, and hyaluronidase with or without epinephrine. Ophthalmology 1991, 98: 239–42.
Oji E and Oji A : Bupivacaine and lignocaine for ophthalmic surgery. Br J Ophthalmol 1987, 71: 66–8.
Calvey TN, Williams NE : Principles and practice of pharmacology for anaesthetists. 2nd ed. Oxford, Blackwell 1991: 228–55.
Donlon JV, Moss J : Plasma catecholamine levels during local anaesthesia for cataract operations. Anaesthesiology 1979, 51: 471–3.
Reynolds F : Adverse effects of local anaesthetics. Br J Anaesth 1987, 59: 78–95.
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Morsman, C., Holden, R. The effects of adrenaline, hyaluronidase and age on peribulbar anaesthesia. Eye 6, 290–292 (1992). https://doi.org/10.1038/eye.1992.56
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DOI: https://doi.org/10.1038/eye.1992.56
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