Abstract
Background
To describe the efficacy of photodynamic therapy (PDT) with verteporfin for the treatment of polypoidal choroidal vasculopathy (PCV).
Methods
This is a retrospective interventional case series of 41 eyes of 40 patients with angiographic evidence of PCV, which had PDT with verteporfin. Pre-treatment best-corrected visual acuity (BCVA) was measured and patients were followed up for at least 12 months with BCVA recorded at each visit.
Results
The mean follow-up time was 23.7 months. Seven of 10 eyes (70%) with juxtafoveal lesions and 17 of 31 eyes (54.8%) with subfoveal lesions had stable or improved vision (loss of ⩽3 lines) at the last follow-up. The mean number of treatments was 1.90. Thirty-three eyes (80.5%) had dry, quiescent scars at last follow-up, six eyes (14.6%) had persistent leakage, and two eyes (4.9%) had evidence of choroidal neovascularisation.
Conclusion
Our results indicate that 24 of 41 eyes (58.5%) with serosanguinous maculopathy secondary to PCV treated with PDT had stable or improved vision (loss of ⩽3 lines) after a mean follow-up of almost 2 years. However, in view of the retrospective nature of this study, the true efficacy of PDT for PCV would have to be evaluated with a larger randomised controlled trial.
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This paper was presented at the 2006 Cannes Retinal Festival, European Vitreoretinal Society and American Society of Retinal Specialists combined meeting. This paper has not been published or submitted for publication in any other journals Financial support: None Proprietary interests: None
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Lee, MW., Yeo, I., Wong, D. et al. Photodynamic therapy with verteporfin for polypoidal choroidal vasculopathy. Eye 23, 1417–1422 (2009). https://doi.org/10.1038/eye.2008.265
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DOI: https://doi.org/10.1038/eye.2008.265
