Abstract
Purpose
To study the natural course of changes observed in the retinal pigment epithelium (RPE) on spectral domain OCT transverse and RPE fit C-scans corresponding to the leakage point observed on fundus fluorescein angiograms in central serous chorioretinopathy (CSC).
Methods
Thirteen patients with acute CSC were prospectively enrolled and followed up for 6 months. All were examined using Zeiss Cirrus HD-OCT Model 4000. Transverse and RPE fit C-scans corresponding to point of leakage were superimposed on an OCT fundus photograph and correlated with the leakage point on a fluorescein angiogram. The RPE alterations observed at the leakage point were noted at presentation and follow-up.
Results
Transverse and RPE fit C-scans showed an irregularity of RPE resembling a ‘honeycomb’ pattern in 11 (85%) eyes at the point corresponding to the fluorescein leakage site. These were observed as pigment epithelium detachment (PED) on Raster line scan. Six of these 11 eyes (54.5%) showed a disruption/breach in the RPE on transverse C-scan and on RPE fit C-scan. All eyes showed a resolution of subretinal fluid with a closure of microrip, and the honeycombed pattern at the leakage site was replaced with RPE hypertrophy.
Conclusion
RPE microrips show spontaneous closure in the natural course of CSC.
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References
Guyer DR, Yannuzzi LA, Slakter JS, Sorenson JA, Ho A, Orlock D . Digital indocyanine green video angiography of central serous chorioretinopathy. Arch Ophthalmol 1994; 112: 1057–1062.
Piccolino FC, Borgia L, Zinicola E, Zingirian M . Indocyanine green angiographic findings in central serous chorioretinopathy. Eye 1995; 9: 324–332.
Prunte C, Flammer AJ . Choroidal capillary and venous congestion in central serous chorioretinopathy. Am J Ophthalmol 1996; 121: 26–34.
Gass JDM . Pathogenesis of disciform detachment of the neuroepithelium II. Idiopathic central serous chorioretinopathy. Am J Ophthalmol 1967; 63: 587–615.
Spaide RF, Campeas L, Haas A, Yannuzzi LA, Fisher YL, Guyer DR et al. Central serous chorioretinopathy in younger and older adults. Ophthalmology 1996; 103: 2070–2079.
Goldstein BG, Pavan PR . Blow-outs in the retinal pigment epithelium. Br J Ophthalmol 1987; 71: 676–681.
Ober MD, Eandi CM, Jampol LM, Fine HF, Yannuzi LA . Focal retinal pigment epithelium breaks in central serous chorioretinopathy. Retin Cases Brief Rep 2007; 1: 271–273.
Fujimoto H, Gomi F, Wakabayashi T, Sawa M, Tsujikawa M, Tano Y . Morphologic changes in acute central serous chorioretinopathy evaluated by fourier-domain optical coherence tomography. Ophthalmology 2008; 115 (9): 1494–1500.
Hirami Y, Tsujikawa A, Sasahara M, Gotoh N, Tamura H, Otani A et al. Alterations of retinal pigment epithelium in central serous chorioretinopathy. Clin Experiment Ophthalmol 2007; 35: 225–230.
Iida T, Hagimura N, Sato T, Kishi S . Evaluation of central serous chorioretinopathy with optical coherence tomography. Am J Ophthalmol 2000; 129: 16–20.
Montero JA, Ruiz-Moreno JM . Optical coherence tomography characterization of idiopathic central serous chorioretinopathy. Br J Ophthalmol 2005; 89: 562–564.
Gupta V, Gupta A, Dogra MR . Atlas: optical coherence tomography of macular diseases and glaucoma. 2nd ed Jaypee Brs Med Publishers (P) Ltd: New Delhi, India, 2006; 72–103.
van Velthoven MEJ, Verbraak FD, Garcia PM, Schlingemann RO, Rosen RB, de Smet MD . Evaluation of central serous retinopathy with en face optical coherence tomography. Br J Ophthalmol 2005; 89: 1483–1488.
Mitarai K, Gomi F, Tano Y . Three-dimensional optical coherence tomographic findings in central serous chorioretinopathy. Graefe's Arch Clin Exp Ophthalmol 2006; 244: 1415–1420.
Marmor MF, Yao X-Y . Conditions necessary for the formation of serous detachment. Experimental evidence from the cat. Arch Ophthalmol 1994; 112: 830–838.
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Gupta, V., Gupta, P., Dogra, M. et al. Spontaneous closure of retinal pigment epithelium microrip in the natural course of central serous chorioretinopathy. Eye 24, 595–599 (2010). https://doi.org/10.1038/eye.2009.193
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DOI: https://doi.org/10.1038/eye.2009.193
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