Abstract
Purpose
To describe the incidence and survival rate of patients with retinoblastoma in Taiwan over a 25-year period, from 1979 to 2003.
Methods
Cases of retinoblastoma have been reported to the Taiwan National Cancer Registry (TNCR) since 1979. Retinoblastoma data from 1979 to 2003 were retrieved from the TNCR databank for analysis of both the incidence and survival rate. Trends in the incidence rate were estimated by calculating the annual percentage change (APC).
Results
From 1979 to 2003, a total of 380 patients (182 [47.9%] females) with retinoblastoma were identified. Of the 380 cases, 359 patients (94.5%) were diagnosed before 5 years of age. The average annual age-standardized incidence rate was 4.45 per million in children under 10 years of age and 8.58 per million in children under 5 years of age. There was a significant increasing trend in the incidence rate over the study period with an APC of 2.3% (P=0.035). Before the implementation of Taiwan's National Health Insurance (NHI) Program in 1995, the mean age at diagnosis was 4.8±13.3 years and the 5-year survival rate was 74.7%. After implementation of the NIH Program, the mean age at diagnosis decreased to 1.6±2.1 years (P<0.001) and the 5-year survival rate increased to 84.7% (P=0.063).
Conclusions
We report the first population-based study on retinoblastoma in Taiwan. There was a significant increasing trend in the incidence rate from 1979 to 2003. Since the implementation of Taiwan's NHI, the mean diagnostic age decreased.
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References
Matthew WW, Barrett GH, Carlos RG . Socioeconomic impact of modern multidisciplinary management of retinoblastoma. Pediatrics 2006; 118: 331–336.
Desjardins L, Doz F, Schlinger P . Le retinoblastome. Ann Pediatr 1996; 43: 359–371.
Shields CL, Shields JA . Recent developments in the management of retinoblastoma. J Pediatr Ophthalmol Strabismus 1999; 36: 8–18.
Su WW, Kao LY . Retinoblastoma in Taiwan: The effect of a government-sponsored national health insurance program on the treatment and survival of patients with retinoblastoma. J Pediatr Ophthalmol Strabismus 2006; 43: 358–362.
MacCarthy A, Draper GJ, Steliarova-Foucher E, Kingston JE . Retinoblastoma incidence and survival in European children (1978–1997). Report from the Automated Childhood Cancer Information System project. Eur J Cancer 2006; 42: 2092–2102.
Saw SM, Tan N, Lee SB, Au Eong KG, Chia KS . Incidence and survival characteristics of retinoblastoma in Singapore from 1968–1995. J Pediatr Ophthalmol Strabismus 2000; 37: 87–93.
The Committee for the National Registry of Retinoblastoma. Survival rate and risk factors for patients with retinoblastoma in Japan. Jpn J Ophthalmol 1992; 36: 121–131.
Cheng CY, Hsu WM . Incidence of eye cancer in Taiwan: an 18-year review. Eye 2004; 18: 152–158.
World Health Organization. International Classification of Disease for Oncology, 2nd ed. World Health Organization: Geneva, 1990.
Ministry of the Interior, R.O.C.. 2003 Taiwan-Fukien Demographic Fact Book, Republic of China. Taipei: Ministry of the Interior: Taipei, Republic of China, 2004.
Department of Health, Executive Yuan, Taiwan ROC 2004 Health and national health insurance annual statistics information service. Available at: (http://www.doh.gov.tw/statistic/index.htm).
Cheng SH, Chiang TL . The effect of universal health insurance on health care utilization in Taiwan: results from a natural experiment. JAMA 1997; 278: 89–93.
Lu JF, Hsiao WC . Development of Taiwan's National Health Accounts. Taiwan Econ Rev 2001; 29: 547–576.
Abramson DH, Beaverson K, Sangani P, Vora PA, Lee TC, Hochberg HM et al. Screening for retinoblastoma: presenting signs as prognosticators of patient and ocular survival. Pediatrics 2003; 112: 1248–1255.
Balmer A, Munier F, Gailloud C . Retinoma. Case studies. Ophthalmic Paediatr Genet 1991; 12: 131–137.
Acknowledgements
We thank the Department of Health, the Executive Yuan, Taiwan, for providing the raw data for this study.
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Chen, YH., Lin, HY., Hsu, WM. et al. Retinoblastoma in Taiwan: incidence and survival characteristics from 1979 to 2003. Eye 24, 318–322 (2010). https://doi.org/10.1038/eye.2009.80
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DOI: https://doi.org/10.1038/eye.2009.80
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