Abstract
Purpose
To determine the prevalence of pulmonary sarcoidosis in patients with uveitis from the University Referral Centre in Thailand and to report on their clinical characteristics.
Methods
We performed a retrospective review of results of radiological examinations of 209 consecutive new patients, diagnosed with uveitis. In patients with signs of pulmonary sarcoidosis, we reviewed clinical characteristics including age, gender, laterality and anatomical location of uveitis, and complications.
Results
From 209 chest X-ray (CXR) examinations, one patient exhibited radiological signs typical of stage 1 sarcoidosis. Chest CT of three patients with posterior multifocal chorioretinitis (PMC) revealed abnormalities suggesting the diagnosis of pulmonary sarcoidosis. All PMC patients were females older than 50 years; they had no pulmonary complaints and their CXRs were without abnormalities.
Conclusion
Ocular sarcoidosis is prevalent in Thailand and our findings suggest that possibly more patients with sarcoidosis would be identified if diagnosis was thought of and ancillary tests were performed.
Similar content being viewed by others
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
References
Michael C . Sarcoidosis. N Engl J Med 2007; 357: 2153–2165.
Margolis R, Lowder CY . Sarcoidosis. Curr Opin Ophthalmol 2007; 18: 470–475.
Sharma OP . Sarcoidosis around the world. Clin Chest Med 2008; 29: 357–363.
Rathinam SR . Global variation and pattern changes in epidemiology of uveitis. Indian J Ophthalmol 2007; 55: 173–183.
Goto H, Mochizuki M, Yamaki K, Kotake S, Usui M, Ohno S . Epidemiological survey of intraocular inflammation in Japan. Jpn J Ophthalmol 2007; 51: 41–44.
Chung YM . Uveitis with biopsy-proven sarcoidosis in Chinese-a study of 60 patients in uveitis clinic over a period of 20 years. J Chin Med Assoc 2007; 70: 492–496.
Yang P, Zhang Z, Zhou H, Li B, Huang X, Gao Y et al. Clinical patterns and characteristics of uveitis in a tertiary center for uveitis in China. Curr Eye Res 2005; 30: 943–948.
Pathanapitoon K, Kunavisarut P, Ausayakhun S, Sirirungsi W, Rothova A . Uveitis in a tertiary ophthalmology centre in Thailand. Br J Ophthalmol 2008; 92: 474–478.
Manonukul J, Wanitphakdeedecha R, Wisuthsarewong W, Thirapote P . Histopathologic aid to diagnosis of sarcoidosis: report of 8 cases. J Med Assoc Thai 2006; 89: 864–871.
Lardenoye CW, Van der Lelij A, de Loos WS, Treffers WF, Rothova A . Peripheral multifocal chorioretinitis: a distinct clinical entity? Ophthalmology 1997; 104: 1820–1826.
Standardization of uveitis nomenclature (SUN) working group. Standardization of uveitis nomenclature for reporting clinical data. Results of the first international workshop. Am J Ophthalmol 2005; 140: 509–516.
Herbort CP, Rao NA, Mochizuki M, members of Scientific Committee of First International Workshop on Ocular Sarcoidosis. International criteria for the diagnosis of ocular sarcoidosis: results of the first International Workshop On Ocular Sarcoidosis (IWOS). Ocul Immunol Inflamm 2009; 17: 160–169.
Khanna A, Sidhu U, Bajwa G, Malhotra V . Pattern of ocular manifestations in patients with sarcoidosis in developing countries. Acta Ophthalmol Scans 2007; 85: 609–612.
Lynch III JP . Computed tomographic scanning in sarcoidosis. Semin Respir Crit Care Med 2003; 24: 393–418.
Kaiser PK, Lowder CY, Sullivan P, Sanislo SR, Kosmorsky GS, Meziane MA et al. Chest computerized tomography in the evaluation of uveitis in elderly women. Am J Ophthalmol 2002; 133: 499–505.
Kawaguchi T, Hanada A, Horie S, Sugamoto Y, Sugita S, Mochizuki M . Evaluation of characteristic ocular signs and systemic investigations in ocular sarcoidosis patients. Jpn J Ophthalmol 2007; 51: 121–126.
Rothova A . Ocular involvement in sarcoidosis. Br J Ophthalmol 2000; 84: 110–116.
Ohara K . Intraocular manifestations of systemic sarcoidosis. Jpn J Ophthalmol 1992; 36: 452–457.
Abad S, Meyssonier V, Allali J, Gouya H, Giraudet AL, Monnet D et al. Association of peripheral multifocal choroiditis with sarcoidosis: a study of thirty-seven patients. Arthritis Rheum 2004; 51: 974–982.
Tabbara KF . Tuberculosis. Curr Opin Ophthalmol 2007; 18: 493–501.
Acknowledgements
Juntima Euathrongchit MD for her advice in evaluation of radiological examinations.
Funding: Supported in part by the combined grants from Dr P Binkhorst Foundation for Ophthalmologic research, Nijmegen; Landelijke stichting voor Blinden en Slechtzienden, Utrecht; Rotterdamse Vereniging Blindenbelangen, Rotterdam; Stichting voor Ooglijders, Rotterdam; Katholieke Stichting voor Blinden en Slechtzienden, Grave, Stichting Oog, ‘s Gravenzande, and Dr FP Fischer Stichting, Amersfoort, the Netherlands.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Rights and permissions
About this article
Cite this article
Pathanapitoon, K., Goossens, J., van Tilborg, T. et al. Ocular sarcoidosis in Thailand. Eye 24, 1669–1674 (2010). https://doi.org/10.1038/eye.2010.107
Received:
Revised:
Accepted:
Published:
Issue date:
DOI: https://doi.org/10.1038/eye.2010.107
Keywords
This article is cited by
-
Uveitis profile and treatment response in Iranian patients with sarcoidosis
International Ophthalmology (2015)
-
Sarcoidosis in tuberculosis-endemic regions: India
Journal of Ophthalmic Inflammation and Infection (2013)