Abstract
Purpose
To evaluate the long-term visual outcome of type 2 diabetic patients receiving early vitrectomy and endolaser for severe vitreous haemorrhage (VH).
Materials and methods
Retrospective case note review of 88 eyes (69 type 2 diabetics and 19 type 1 diabetics) of 80 patients who underwent vitrectomy and endolaser within 6 months of VH. Post-operative and most recent VA, in addition to long-term retinopathy grading, were analysed. A subset of patients fulfilling the criteria for the Diabetic Retinopathy Vitrectomy Study was compared with this study.
Results
Mean pre-operative visual acuity (VA) in the type 2 group was 0.64 logMAR, with 1 eye showing perception light (PL), 10 eyes detecting hand movements (HMs), and 7 eyes counting fingers (CFs). At the 2-week post-operative visit, the mean VA had improved to 0.46 logMAR, with two eyes showing PL, two eyes detecting HM, and one eye CF (P=0.0002); at the last review, mean VA score was 0.36 logMAR, with three eyes showing PL and four eyes detecting HM (P=0.0008). Mean pre-operative VA in the type 1 group was 0.47 logMAR, with one eye showing PL, one eye detecting HM, and two eyes CF. At the 2-week post-operative visit, the mean VA had improved to 0.37 logMAR, with one eye showing PL (P=0.002), and at the latest review, the mean VA was 0.20 logMAR (P=0.027).
Conclusion
Our study shows that type 2 DM patients can observe improvement in VA and stabilisation of their proliferative retinopathy after early vitrectomy and endolaser for vitreous haemorrahage, which is maintained after long-term follow-up.
Similar content being viewed by others
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
References
Klein R . The epidemiology of diabetic retinopathy: findings from the Wisconsin epidemiological study of diabetic retinopathy. Int Ophthalmol Clin 1987; 27: 230–238.
Congdon N, O’Colmain B, Klaver CC, Klein R, Muñoz B, Friedman DS, et al. Eye Diseases Prevalence Research Group. Causes and prevalence of visual impairment among adults in the United States. Arch Ophthalmol 2004; 122: 477–485.
Fong DS, Ferris FL, Aiello LO, Klein R . Diabetic retinopathy. Diabetes Care 2004; 27: 2540–2553.
Joussen A, Smyth N, Niessen C . Pathophysiology of diabetic macular edema. Dev Ophthalmol 2007; 39: 1–12.
Adamis AP, Shima DT . The role of vascular endothelial growth factor in ocular health and disease. Retina 2005; 25: 111–118.
Dodson PM . Management of diabetic retinopathy; could lipid-lowering be a worthwhile modality? Eye 2009; 23: 997–1003.
Takahashi M, Trempe CL, Maguire K, McMeel JW . Vitreoretinal relationship in diabetic retinopathy. A biomicroscopic evaluation. Arch Ophthalmol 1981; 99: 241–245.
The Diabetic Retinopathy Vitrectomy Study Research Group. Early vitrectomy for severe vitreous hemorrhage in diabetic retinopathy. Two year results of randomized trial. Diabetic Retinopathy Vitrectomy Study report 2. Arch Ophthalmol 1985; 103: 1644–1652.
The Diabetic Retinopathy Vitrectomy Study Research Group. Early vitrectomy for severe vitreous hemorrhage in diabetic retinopathy. Four year results of randomized trial. Diabetic Retinopathy Vitrectomy Study report 5. Arch Ophthalmol 1990; 108: 958–964.
Aaberg TM, Abrams GW . Changing indications and technique for vitrectomy in management of complications of diabetic retinopathy. Ophthalmology 1987; 94: 775–779.
Machemer R, Hickingbotham D . The tree-port microcannular system for closed vitrectomy. Am J Ophthalmol 1985; 100: 590–592.
De Bustros S, Thompson JT, Michels RG, Rice TA . Vitrectomy for progressive proliferative diabetic retinopathy. Arch Ophthalmol 1987; 105: 196–199.
Thompson JT, Glaser BM, Michels GR, de Bustros S . The use of intravitreal thrombin to control hemorrhage during vitrectomy. Ophthalmology 1986; 93: 279–282.
Fleischman JA, Swartz M, Dixon JA . Argon laser endophotocoagulation. An intraoperative trans-pars plana technique. Arch Ophthalmol 1981; 99: 1610–1612.
Landers III MB, Trese MT, Stefansson E, Bessler M . Argon laser intraocular photocoagulation. Ophthalmology 1982; 89: 785–788.
Parke II DW, Aaberg TM . Intraocular argon laser photocoagulation in the management of severe proliferative vitreoretinopathy. Am J Ophthalmol 1984; 97: 434–443.
Liggett PE, Lean JS, Barlow WE, Ryan SJ . Intraoperative argon endophotocoagulation for recurrent vitreous hemorrhage after vitrectomy for diabetic retinopathy. Am J Ophthalmol 1987; 103: 146–149.
Chaudhry NA, Lim ES, Saito Y, Mieler WF, Liggett PE, Filatov V . Early vitrectomy and endolaser photocoagulation in patients with type 1 diabetes and severe vitreous hemorrhage. Ophthalmology 1995; 102: 1164–1169.
The Diabetic Retinopathy Study Research Group. Preliminary report on effects of photocoagulation therapy. Am J Ophthalmol 1976; 81: 383–396.
The Diabetic Retinopathy Study Research Group. Photocoagulation treatment of proliferative diabetic retinopathy: the second report of Diabetic Retinopathy Study findings. Ophthalmology 1978; 85: 82–106.
The Diabetic Retinopathy Study Research Group. Photocoagulation treatment of proliferative diabetic retinopathy. Clinical application of Diabetic Retinopathy Study (DRS) findings, DRS report number 8. Ophthalmology 1981; 88: 583–600.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Additional information
This work has been presented at the Oxford Ophthalmological Congress in July 2010 and American Academy of Ophthalmology meeting in October 2010.
Rights and permissions
About this article
Cite this article
Ratnarajan, G., Mellington, F., Saldanha, M. et al. Long-term visual and retinopathy outcomes in a predominately type 2 diabetic patient population undergoing early vitrectomy and endolaser for severe vitreous haemorrhage. Eye 25, 704–709 (2011). https://doi.org/10.1038/eye.2011.65
Received:
Revised:
Accepted:
Published:
Issue date:
DOI: https://doi.org/10.1038/eye.2011.65
Keywords
This article is cited by
-
Therapie der proliferativen diabetischen Retinopathie
Der Diabetologe (2018)


