Abstract
Aims
To examine the rate of macular thickness loss using time-domain optical coherence tomography (OCT) in functionally progressing versus non-progressing eyes, determined by standard automated perimetry (SAP).
Methods
Glaucoma suspects (GS) and glaucomatous (G) eyes underwent SAP and OCT imaging every 6 months. Functional progression was determined using pointwise linear regression, defined as 2 contiguous locations losing ≥1.0 dB/year at P<1.0% in the same hemifield. The annual rate of macular thickness loss was calculated from inner and outer regions of the macular map.
Results
72 eyes (43 GS and 29G) with ≥30 months of follow-up were enroled. Fourteen eyes demonstrated SAP progression. The annual rate of macular thickness loss (μm/year) in progressing eyes was faster (all P<0.05) than non-progressing eyes in temporal outer (−1.90±2.97 vs 0.33±2.77), nasal inner (−1.70±2.66 vs 0.14±2.76), superior inner (−2.15±4.57 vs 0.51±2.99), temporal inner quadrants (−2.58±5.05 vs −0.38±2.34), and the average of inner macular quadrants (−1.84±2.90 vs 0.03±2.10). The rate of loss in the nasal inner (P=0.02) and temporal outer (P=0.02) macular regions was associated with optic disc haemorrhage.
Conclusions
Eyes with SAP progression have significantly greater rates of macular thickness loss consistent with glaucomatous retinal ganglion cell atrophy, as compared with non-progressing eyes.
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Acknowledgements
NIH Grant R01-EY013516, Bethesda, Maryland; P30EY014801 University of Miami core grant; an unrestricted grant from Research to Prevent Blindness, New York, NY, USA; The Maltz Family Endowment for Glaucoma Research, Cleveland, OH, USA; a grant from Mr Barney Donnelley, Palm Beach, FL, USA; and The Kessel Foundation, Bergenfield, NJ, USA. The sponsor or funding organization had no role in the design or conduct of this research.
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Dr. Greenfield has received research support from Carl Zeiss Meditec, Dublin, CA, USA. The other authors declare no conflict of interest.
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Niles, P., Greenfield, D., Sehi, M. et al. Detection of progressive macular thickness loss using optical coherence tomography in glaucoma suspect and glaucomatous eyes. Eye 26, 983–991 (2012). https://doi.org/10.1038/eye.2012.76
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DOI: https://doi.org/10.1038/eye.2012.76
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