Abstract
Purpose
To assess the anterior chamber (AC) characteristics and its correlation to laser flare photometry immediately after femtosecond laser-assisted capsulotomy and photodisruption.
Patients and methods
The study included 97 cataract eyes (n=97, mean age 68.6 years) undergoing femtosecond laser-assisted cataract surgery (FLACS). Three cohorts were analysed relating to the flare photometry directly post femtosecond laser treatment (flare <100 n=28, 69.6±7 years; flare 100–249 n=47, 67.7±8 years; flare >249 photon counts per ms cohort n=22, 68.5±10 years). Flare photometry (KOWA FM-700), corneal topography (Oculus Pentacam, Germany: AC depth, volume, angle, pachymetry), axial length, pupil diameter, and endothelial cells were assessed before FLACS, immediately after femtosecond laser treatment and 1 day postoperative (LenSx Alcon, USA). Statistical data were analysed by SPSS v19.0, Inc.
Results
The AC depth, AC volume, AC angle, central and thinnest corneal thickness showed a significant difference between flare <100 vs flare 100–249 10 min post femtosecond laser procedure (P=0.002, P=0.023, P=0.007, P=0.003, P=0.011, respectively). The AC depth, AC volume, and AC angle were significantly larger (P=0.001, P=0.007, P=0.003, respectively) in the flare <100 vs flare >249 cohort 10 min post femtosecond laser treatment.
Conclusions
A flat AC, low AC volume, and a narrow AC angle were parameters associated with higher intraocular inflammation. These criteria could be used for patient selection in FLACS to reduce postoperative intraocular inflammation.
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References
Nagy Z . New technology update: femtosecond laser in cataract surgery. Clin Ophthalmol 2014; 8: 1157–1167.
Nagy Z, Mastropasqua L, Knorz M . The use of femtosecond lasers in cataract surgery: review of the published results with the Lensx system. J Refract Surg 2014; 30 (11): 730–740.
Nagy Z, Takacs A, Filkorn T, Sarayba M . Initial clinical evaluation of an intraocular femtosecond laser in cataract surgery. J Refract Surg 2009; 25: 1053–1060.
Kranitz K, Takacs A, Muhaltz K, Kovács I, Knorz MC, Nagy ZZ . Femtosecond laser and manual continuous curvilinear capsulorrhexis parameters and their effects on intraocular lens centration. J Refract Surg 2011; 27: 558–563.
Alio JL, Abdou AA, Soria F, Javaloy J, Fernández-Buenaga R, Nagy ZZ et al. Femtosecond laser cataract incision morphology and corneal higher order aberration analysis. J Refract Surg 2013; 29: 590–595.
Kohnen T, Klaproth O, Ostovic M, Hengerer F, Mayer W . Morphological changes in the edge structures following femtosecond laser capsulotomy with varied patient interfaces and different energy settings. Graefes Arch Clin Exp Ophthalmol 2014; 252 (2): 293–298.
Tyndall J . On the blue of the sky, the polarization of the skylight, and on the polarization of light by cloudy matter generally. Philos Mag J Sci 37: 384–404.
Hogan MJ, Kimura SJ, Thygeson P . Signs and symptoms of Uveitis. I. Anterior uveitis. Am J Ophthalmol. 1959; 47: 155–170.
Ladas JG, Wheeler NC, Morhun PJ, Rimmer SO, Holland GN . Laser flare-cell photometry: Methodology and clinical applications. Surv Ophthalmol 2005; 50: 27–47.
Konstantopoulou K, Del’Omo R, Morley AM, Karagiannis D, Bunce C, Pavesio C . A comparative study between clinical grading of anterior chamber flare and flare reading using the Kowa laser flare meter. Int Ophthalmol 2012; 35 (5): 629–633.
Shah SM, Spalton DJ, Taylor JC . Correlations between laser flare measurements and anterior chamber protein concentrations. Invest Ophthalmol Vis Sci. 1992; 33: 2878–2884.
Magalhaes FP, Costa EF, Cariello AJ, Rodrigues EB, Hofling-Lima AL . Comparative analysis of the nuclear lens opalescence by the Lens Opacities Classification System III with nuclear density values provided by Oculus Pentacam: A cross-section study using Pentacam nucleus staging software. Arq Bras Oftalmol 2011; 74: 110–113.
Kovacs I, Kranitz K, sandor GL, Knorz MC, Donnenfeld ED, Nuijts RM et al. The effect of femtosecond laser capsulotomy on the development of posterior capsule opacification. J Refract Surg 2014; 30: 154–158.
Bernasconi O, Papadia M, Herbort CP . Sensitivity of laser flare photometry compared to slit-lamp cell evaluation in monitoring anterior chamber inflammation in uveitis. Int Ophthalmol. 2010; 30: 495–500.
Ursell PG, Spalton DJ, Tilling K . Relation between postoperative blood-aqueous barrier damage and LOCS III cataract gradings following routine phacoemulsification surgery. Br J Ophthalmol. 1997; 81 (7): 544–547.
Oshika T, Kato S . Changes in aqueous flare and cells after mydriasis. Jpn J Ophthalmol 1989; 33: 271–278.
Liu Y, Luo L, He M, Liu X . Disorders of the blood-aqueous barrier after phacoemulsification in diabetic patients. Eye (Lond) 2004; 18 (9): 900–904.
Zarnowski T, Chmiel M, Haszcz D, Zagórski Z . Evaluation of astigmatism and blood-aqueous barrier breakdown following procedures in the anterior eye segment. Klin Oczna 1998; 100 (1): 11–14.
Abell RG, Kerr NM, Vote BJ . Anterior chamber flare after femtosecond laser–assisted cataract surgery. J Cataract Refract Surg. 2013; 39: 1321–1326.
Schauersberger J, Kruger A, Müllner-Eidenböck A, Petternel V, Abela C, Svolba G et al. Long-term disorders of the blood-aqueous barrier after small-incision cataract surgery. Eye (Lond) 2000; 14: 61–63.
Agra C, Agra L, Dantas J, Faria e Arantes TE, de Andrade Neto JL . Anterior segment optical coherence tomography in acute anterior uveitis. Arq Bras Oftalmol 2014; 77 (1): 1–3.
Heinz C, Taneri S, Roesel M, Heiligenhaus A . Influence of corneal thickness changes during active uveitis on Goldmann applanation and dynamic contour tonometry. Ophthalmic Res 2012; 48 (1): 38–42.
Otsuki T, Shimizu K, Igarashi A, Kamiya K . Usefulness of anterior chamber depth measurement for efficacy assessment of steroid pulse therapy in patients with Vogt-Koyanagi-Harada disease. Jpn J Ophthalmol 2010; 54 (5): 396–400.
Kacerovská J, Kacerovský M, Kadlec R . Development of number of endothelial cells after cataract surgery performed by femtolaser in comparison to conventional phacoemulsification. Cesk Slov Oftalmol 2013; 69 (5): 215–218.
Takacs AI, Kovacs I, Mihaltz K, Filkorn T, Knorz MC, Nagy ZZ . Central corneal volume and endothelial cell count following femtosecond laser-assisted refractive cataract surgery compared to conventional phacoemulsification. J Refract Surg 2012; 28: 387–391.
Schultz T, Joachim SC, Kuehn M, Dick HB . Changes in prostaglandin levels in patients undergoing femtosecond laser-assisted cataract surgery. J Refract Surg 2013; 29 (11): 742–747.
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Pahlitzsch, M., Torun, N., Pahlitzsch, M. et al. Correlation between anterior chamber characteristics and laser flare photometry immediately after femtosecond laser treatment before phacoemulsification. Eye 30, 1110–1117 (2016). https://doi.org/10.1038/eye.2016.110
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DOI: https://doi.org/10.1038/eye.2016.110
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