Abstract
Purpose
Autosomal-dominant optic atrophy (ADOA), often associated with mutations in the OPA1 gene (chromosome 3q28-q29) is rarely reported in Asia. Our aim was to identify and describe this condition in an Asian population in Singapore.
Patients and methods
Preliminary cross-sectional study at the Singapore National Eye Centre, including patients with clinical suspicion of ADOA, who subsequently underwent genetic testing by direct sequencing of the OPA1 gene.
Results
Among 12 patients (10 families) with clinically suspected ADOA, 7 patients (5 families) from 3 different ethnic origins (Chinese, Indian, and Malay) carried a heterozygous pathogenic variant in the OPA1 gene. The OPA1 mutations were located on exons 8, 9, 11, and 17: c.869G>A (p.Arg290Glu), c.892A>G (p.Ser298Gly), c.1140G>A (splicing mutation), and c.1669C>T (p.Arg557*), respectively. One splicing mutation (c.871-1G>A) was identified in intron 8. We also identified a novel mutation causing optic atrophy and deafness (c.892A>G (p.Ser298Gly)). Among the phenotypic features, colour pupillometry disclosed a dissociation between low vision and preserved pupillary light reflex in ADOA.
Conclusion
We report the first cases of genetically confirmed OPA1-related ADOA from Singapore, including a novel mutation causing ‘ADOA plus’ syndrome. Further epidemiological studies are needed in order to determine the prevalence of ADOA in South-East Asia.
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Acknowledgements
This work was supported by the National Medical Research Council, Singapore (Grant Nos: NMRC/CIRG/1401/2014(DM) and NMRC/NIG/1000/2009 (JJG)) and the Singapore National Eye Centre Health Research Endowment Fund, Singapore (Grant No: 1005/20/2013 (DM)). The funding organisations had no role in the design and conduct of the research.
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Loo, J., Singhal, S., Rukmini, A. et al. Multiethnic involvement in autosomal-dominant optic atrophy in Singapore. Eye 31, 475–480 (2017). https://doi.org/10.1038/eye.2016.255
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DOI: https://doi.org/10.1038/eye.2016.255
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