Abstract
With the aim of identifying more novel natural epothilone derivatives produced by the epothilones A and B producing strain Sorangium cellulosum strain So0157-2, a large-scale fermentation (5000 l) of the strain was carried out. As a result, five new epothilone variants (1–5) were isolated from the fermentation broth. Their structures were established as 3-α-D-arabinofuranosides of epothilones A (1), B (2), D (3), C9 (4) and 8-demethyl epothilone A (5) by extensive NMR analysis and chemical methods. Bioassay results showed that compounds 1 and 2 had a weaker cytotoxic activity than did epothilone B.
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Wang, J., Zhang, H., Ying, L. et al. Five new epothilone metabolites from Sorangium cellulosum strain So0157-2. J Antibiot 62, 483–487 (2009). https://doi.org/10.1038/ja.2009.55
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DOI: https://doi.org/10.1038/ja.2009.55
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