Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
References
Otoguro, K. et al. Selective and potent in vitro antitrypanosomal activities of 10 microbial metabolites. J. Antibiot. 61, 372–378 (2008).
Ishiyama, A. et al. In vitro and in vivo antitrypanosomal activities of two microbial metabolites, KS-505a and alazopeptin. J. Antibiot. 61, 627–632 (2008).
Ishiyama, A. et al. In vitro and in vivo antitrypanosomal activities of three peptide antibiotics: leucinostatin A and B, alamethicin I and tsushimycin. J. Antibiot. 62, 303–308 (2009).
Otoguro, K. et al. In vitro and in vivo antiprotozoal activities of bispolides and their derivatives. J. Antibiot. 63, 275–277 (2010).
Otoguro, K. et al. In vitro and in vivo anti-Trypanosoma brucei activities of phenazinomycin and related compounds. J. Antibiot. 63, 579–581 (2010).
Iwatsuki, M. et al. In vitro antitrypanosomal activity of 12 low-molecular-weight antibiotics and observations of structure/activity relationships. J. Antibiot. 63, 619–622 (2010).
Inahashi, Y. et al. Spoxazomicins A-C, novel antitrypanosomal alkaloids produced by an endophytic actinomycete, Streptosporangium oxazolinicum K07-0460T. J. Antibiot. 64, 303–307 (2011).
Tsukuda, E. et al. EI-1507-1 and -2, novel interleukin-1β converting enzyme inhibitors produced by Streptomyces sp. E-1507. J. Antibiot. 49, 333–339 (1996).
Koizumi, F., Matsuda, Y. & Nakanishi, S. EI-1941-1 and -2, novel interleukin-1β converting enzyme inhibitors produced by Farrowia sp. EI-1941. J. Antibiot. 56, 464–469 (2003).
Shoji, M. et al. Enantio- and diastereoselective total synthesis of EI-1941-1, -2, and -3, inhibitors of interleukin-1β converting enzyme, and biological properties of their derivatives. J. Org. Chem. 70, 9905–9915 (2005).
Gehrt, A., Erkel, G., Anke, T. & Sterner, O. Cycloepoxydon, 1-hydroxy-2- hydroxymethyl-3-pent-1-enylbenzene and 1-hydroxy-2- hydroxymethyl-3-pent-1, 3-dienylbenzene, new inhibitors of eukaryotic signal transduction. J. Antibiot. 51, 455–463 (1998).
Hara, M. et al. DC 107, a novel antitumor antibiotic produced by Streptomyces sp. J. Antibiot. 42, 333–335 (1989).
Asai, A. et al. Thiol-mediated DNA alkylation by the novel antitumor antibiotic leinamycin. J. Am. Chem. Soc. 118, 6802–6803 (1996).
Nakai, R. et al. UCS1025A, a novel antibiotic produced by Acremonium sp. J. Antibiot. 53, 294–296 (2000).
Nakai, R. et al. Telomerase inhibitors identified by a forward chemical genetics approach using a yeast strain with shortened telomere length. Chem. Biol. 13, 183–190 (2006).
Acknowledgements
This work was supported, in part, by funds from the Drugs for Neglected Diseases initiative (DNDi), Quality Assurance Framework of Higher Education from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan and the All Kitasato Project Study (AKPS). We are grateful to Ms H Sekiguchi and Mr T Furusawa (Kitasato University) for their technical assistance. We also thank Dr M Ichimura (Kyowa Hakko Kirin) for providing antibiotics and Dr H Nakano (Kitasato University) for valuable discussion.
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Ishiyama, A., Otoguro, K., Iwatsuki, M. et al. In vitro antitrypanosomal activity of five low-MW antibiotics. J Antibiot 65, 113–114 (2012). https://doi.org/10.1038/ja.2011.118
Received:
Revised:
Accepted:
Published:
Issue date:
DOI: https://doi.org/10.1038/ja.2011.118