Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
References
Fiedler, H. P. et al. Marine actinomycetes as a source of novel secondary metabolites. Antonie van Leeuwenhoek. 87, 37–42 (2005).
Maskey, R. P. et al. Anti-cancer and antibacterial trioxacarcins with high anti-malaria activity from a marine streptomycete and their absolute stereochemistry. J. Antibiot. 57, 771–779 (2004).
Gorajana, A. et al. 1-hydroxy-1-norresistomycin, a new cytotoxic compound from a marine actinomycete, Streptomyces chibaensis AUBN(1)/7. J. Antibiot. 58, 526–531 (2005).
Kock, I., Maskey, R. P., Biabani, M. A., Helmke, E. & Laatsch, H. 1-hydroxy-1-norresistomycin and resistoflavin methyl ether: New antibiotics from marine derived streptomycetes. J. Antibiot. 58, 530–535 (2005).
Werner, G., Hagenmaier, H., Drautz, H., Baumgartner, A. & Zähner, H. Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity. J. Antibiot. 37, 110–117 (1984).
Kretschmer, A., Dorgerloh, M., Deeg, M. & Hagenmaier, H. The structures of novel insecticidal macrolides bafilomycins D and E, and oxohygrolidin. Agric. Biol. Chem. 49, 2509–2511 (1985).
Carr, G. et al. Bafilomycins produced in culture by Streptomyces spp. isolated from marine habitats are potent inhibitors of autophagy. J. Nat. Prod. 73, 422–427 (2010).
Bowman, E. J., Siebers, A. & Altendorf, K. Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells. Proc. Natl Acad. Sci. USA. 85, 7972–7976 (1988).
Drose, S. et al. Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases. Biochem. 32, 3902–3906 (1993).
Ueda, J. Y., Hashimoto, J., Yamamura, H., Hayakawa, M., Takagi, M. & Shin-ya, K. A new 16-membered tetraene macrolide JBIR-100 from a newly identified Streptomyces species. J. Antibiot. 63, 627–629 (2010).
Wang, Y. R., Inoue, T. & Forgac, M. Subunit a of the yeast V-ATPase participates in binding of bafilomycin[J]. J. Biol. Chem. 280, 40481–40488 (2005).
van Schalkwyk, D. A. et al. Inhibition of plasmodium falciparum pH regulation by small molecule indole derivatives results in rapid parasite death. Biochem. Pharmacol. 79, 1291–1299 (2010).
Baker, G. H., Brown, P. J., Dorgan, R. J. J. & Everett, J. R. The conformational analysis of bafilomycin A1 . J. Chem. Soc., Perkin Trans. 2, 1073–1079 (1989).
Zhang, D. J., Liu, R. F., Li, Y. G., Tao, L. M. & Tian, L. Two new antifungal cyclic lipopeptides from Bacillus marinus B-9987. Chem. Pharm. Bull. 58, 1630–1634 (2010).
Acknowledgements
This work was financially supported by the High-Tech Program (863 Program) of China (2008AA09Z407) and National Basic Research Program (973 Program) of China (2010CB126100).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Zhang, Dj., Wei, G., Wang, Y. et al. Bafilomycin K, a new antifungal macrolide from Streptomyces flavotricini Y12-26. J Antibiot 64, 391–393 (2011). https://doi.org/10.1038/ja.2011.12
Received:
Revised:
Accepted:
Published:
Issue date:
DOI: https://doi.org/10.1038/ja.2011.12
Keywords
This article is cited by
-
Streptomyces monashensis sp. nov., a novel mangrove soil actinobacterium from East Malaysia with antioxidative potential
Scientific Reports (2019)
-
Characterization of a gamma-butyrolactone synthetase gene homologue (stcA) involved in bafilomycin production and aerial mycelium formation in Streptomyces sp. SBI034
Applied Microbiology and Biotechnology (2016)
-
Bafilomycin L, a new inhibitor of cholesteryl ester synthesis in mammalian cells, produced by marine-derived Streptomyces sp. OPMA00072
The Journal of Antibiotics (2015)
-
Antifungal Macrolides from Streptomyces cavourensis YY01-17
Chemistry of Natural Compounds (2013)
