Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
References
Otoguro, K. et al. In vitro and in vivo antiprotozoal activities of bispolides and their derivatives. J. Antibiot. 63, 275–277 (2010).
Otoguro, K. et al. Promising lead compounds for novel antiprotozoals. J. Antibiot. 63, 381–384 (2010).
Otoguro, K. et al. Potent antimalarial activities of the polyether antibiotic, X-206. J. Antibiot. 54, 658–663 (2001).
Iwatsuki, M. et al. In vitro and in vivo antimalarial activity of puberulic acid and its new analogs, viticolins A-C, produced by Penicillium sp. FKI-4410. J. Antibiot. 64, 183–188 (2011).
Otoguro, K. et al. Selective and potent in vitro antitrypanosomal activities of 10 microbial metabolites. J. Antibiot. 61, 372–378 (2008).
Ishiyama, A. et al. In vitro and in vivo antitrypanosomal activities of two microbial metabolites, KS-505a and Alazopeptin. J. Antibiot. 61, 627–632 (2008).
Yamamura, H. et al. Application of sucrose-gradient centrifugation for selective isolation of Nocardia spp. from soil. J. Appl. Microbiol. 95, 677–685 (2003).
Argoudelis, A. D., Jahnke, H. K. & Fox, J. A. Pactamycin, a new antitumor antibiotic. II. Isolation and characterization. Antimicrob. Agents Chemother. 1–1961, 191–197 (1962).
Kondo, S., Shimura, M., Sezaki, M., Satō, K. & Hara, T. Isolation and characterization of cranomycin, a new antibiotic. J Antibiot. Ser. A 17, 230–233 (1964).
Weller, D. D., Haber, A., Rinehart, K. L. Jr. & Wiley, P. F. Carbon-13 nuclear magnetic resonance assignments to pactamycin and related compounds. J. Antibiot. 31, 997–1006 (1978).
Brodersen, D. E. et al. The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30s ribosomal subunit. Cell 103, 1143–1154 (2000).
Ito, T. et al. Deciphering pactamycin biosynthesis and engineered production of new pactamycin analogues. Chem. BioChem. 10, 2253–2265 (2009).
Hanessian, S. et al. Total synthesis of pactamycin. Angew Chem. Int. Ed. Engl. 50, 3497–3500 (2011).
Acknowledgements
This study was supported, in part, by the funds from the Drugs for Neglected Diseases initiative (DNDi), Quality Assurance Framework of Higher Education from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) in Japan, and All Kitasato Project Study (AKPS). We are grateful to Ms Hitomi Sekiguchi and Mr Toshiaki Furusawa for their technical assistance, Dr Kenichiro Nagai and Ms Noriko Sato, School of Pharmacy, Kitasato University for the measurements of mass and NMR spectra, and Dr Kazuro Shiomi, Kitasato Institute for Life Sciences, Kitasato University for proofreading this paper.
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Iwatsuki, M., Nishihara-Tsukashima, A., Ishiyama, A. et al. Jogyamycin, a new antiprotozoal aminocyclopentitol antibiotic, produced by Streptomyces sp. a-WM-JG-16.2. J Antibiot 65, 169–171 (2012). https://doi.org/10.1038/ja.2011.136
Received:
Revised:
Accepted:
Published:
Issue date:
DOI: https://doi.org/10.1038/ja.2011.136
Keywords
This article is cited by
-
Clonocoprogens A, B and C, new antimalarial coprogens from the Okinawan fungus Clonostachys compactiuscula FKR-0021
The Journal of Antibiotics (2020)
-
The secondary metabolite pactamycin with potential for pharmaceutical applications: biosynthesis and regulation
Applied Microbiology and Biotechnology (2019)
-
Global and pathway-specific transcriptional regulations of pactamycin biosynthesis in Streptomyces pactum
Applied Microbiology and Biotechnology (2018)
