Abstract
New bioactive secondary metabolites, called abenquines, were found in the fermentation broth of Streptomyces sp. strain DB634, which was isolated from the soils of the Chilean highland of the Atacama Desert. They are composed of an amino acid linked to an N-acetyl-aminobenzoquinone. Isolation of the abenquines (1–4), their structure elucidation by NMR analysis and MS, as well as the kinetics of their production are presented. The abenquines show inhibitory activity against bacteria, dermatophytic fungi and phosphodiesterase type 4b. The amino acid attached to the quinone is relevant to the enzyme inhibitory activity.
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Acknowledgements
We gratefully thank R Schmaljohann for microscopy, G Kohlmeyer-Yilmaz, M Höftmann, as well as Dr F Sönnichsen for running and processing NMR experiments. This study is from the Kieler Wirkstoff-Zentrum, which is supported by the Ministry of Science, Economic Affaires and Transport of the State of Schleswig-Holstein (Germany), in the frame of the ‘Future Program for Economy’, which is co-financed by the European Union (EFRE).
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Dedicated to Professor Gerhard Bringmann on the occasion of his 60th birthday.
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Schulz, D., Beese, P., Ohlendorf, B. et al. Abenquines A–D: aminoquinone derivatives produced by Streptomyces sp. strain DB634. J Antibiot 64, 763–768 (2011). https://doi.org/10.1038/ja.2011.87
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DOI: https://doi.org/10.1038/ja.2011.87
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