Abstract
Three new 22-membered macrolactone antibiotics, atacamycins A–C, were produced by Streptomyces sp. C38, a strain isolated from a hyper-arid soil collected from the Atacama Desert in the north of Chile. The metabolites were discovered in our HPLC-diode array screening and isolated from the mycelium by extraction and chromatographic purification steps. The structures were determined by mass spectrometry and NMR experiments. Atacamycins A, B and C exhibited moderate inhibitory activities against the enzyme phosphodiesterase (PDE-4B2), whereas atacamycin A showed a moderate antiproliferative activity against adeno carcinoma and breast carcinoma cells.
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Acknowledgements
ATB thanks The Leverhulme Trust for an Emeritus Fellowship, and ATB and JAA the Royal Society for an International Joint Project Grant (JP100654). This research was supported by grants from the Deutsche Forschungsgemeinschaft and the Cluster of Excellence ‘Unifying Concepts in Catalysis’ coordinated by the Technische Universität Berlin. JFI and JW are grateful to A Erhard for performing the activity tests as well as the Ministry of Science, Economic Affaires and Transport of the State of Schleswig-Holstein (Germany) for supporting the Kieler Wirkstoff–Zentrum in the frame of the ‘Future Program for Economy’, which is co-financed by the European Union (EFRE).
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Art. no. 61 in ‘Biosynthetic Capacities of Actinomycetes’. Art. no. 60: see ref. 19.
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Nachtigall, J., Kulik, A., Helaly, S. et al. Atacamycins A–C, 22-membered antitumor macrolactones produced by Streptomyces sp. C38. J Antibiot 64, 775–780 (2011). https://doi.org/10.1038/ja.2011.96
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DOI: https://doi.org/10.1038/ja.2011.96
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