Abstract
Two new polyketides, 6,8,5′6′-tetrahydroxy-3′-methylflavone (1) and paecilin C (2), together with six known analogs secalonic acid D (3), secalonic acid B (4) penicillixanthone A (5), emodin (6), citreorosein (7) and isorhodoptilometrin (8) were obtained from a broth of gorgonian coral-associated fungus Penicillium sp. SCSGAF 0023. Compounds 1 and 6–8 had significant antifouling activity against Balanus amphitrite larvae settlement with EC50 values of 6.7, 6.1, 17.9 and 13.7 μg ml−1, respectively, and 3–5 showed medium antibacterial activity against four tested bacterial strains. This was the first report of antibacterial activity of 3–5 against marine bacteria and antifouling activity of 6–8 against marine biofouling organism’s larvae. The results indicated that gorgonian coral-associated fungus Penicillium sp. SCSGAF 0023 strain could produce antifouling and antibacterial compounds that might aid the host gorgonian coral in protection against marine pathogen bacteria, biofouling organisms and other intruders.
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Acknowledgements
We are grateful to the National Basic Research Program of China (grant 2010CB833803), the National Natural Science Foundation of China (grant 40931160435, 40976090), the Research Supported by the CAS/SAFEA International Partnership Program for Creative Research Teams (grant KZCX2-YW-T001) and the Knowledge Innovation Program of Chinese Academy of Science (grant KSCX2-EW-G-12B) for financial support.
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Bao, J., Sun, YL., Zhang, XY. et al. Antifouling and antibacterial polyketides from marine gorgonian coral-associated fungus Penicillium sp. SCSGAF 0023. J Antibiot 66, 219–223 (2013). https://doi.org/10.1038/ja.2012.110
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DOI: https://doi.org/10.1038/ja.2012.110
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