Abstract
A new trehalose analog, lentztrehalose [4-O-(2,3-dihydroxy-3-methylbutyl)trehalose], was isolated from an actinomycete Lentzea sp. Lentztrehalose is only weakly hydrolyzed by the trehalose-hydrolyzing enzyme, trehalase, so can be regarded as an enzyme-stable analog of trehalose. Although lentztrehalose does not show apparent toxicity to mammalian cells and microbes, it has antitumor activity in mice bearing S-180 sarcoma and Ehrlich carcinoma cells. In ovariectomized mice, lentztrehalose displayed a bone reinforcement effect in the femur that was superior to trehalose and induced non-morbid suppression of weight gain comparable with trehalose. These results indicate that enzyme-stable analogs of trehalose, such as lentztrehalose, may be more beneficial for human health and thus have potential as substitutes for trehalose as a sweetener.
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Acknowledgements
We appreciate the help of Prof Sachi SriKantha, Gifu University, for his critical reading of this manuscript. We acknowledge the assistance of Dr M Igarashi, Dr R Sawa, Ms Y Kubota, Ms H Soutome, Mr K Inoue, Ms C Hayashi, Dr Y Takahashi and Dr K Yamazaki at the Institute of Microbial Chemistry for their support for this study and helpful discussion. This study was partially supported by the Japan Society for the Promotion of Science.
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Wada, Si., Ohba, Si., Someno, T. et al. Structure and biological properties of lentztrehalose: a novel trehalose analog. J Antibiot 67, 319–322 (2014). https://doi.org/10.1038/ja.2013.143
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DOI: https://doi.org/10.1038/ja.2013.143
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