Abstract
The novel antifungal macrocyclic lipopeptidolactone, KB425796-A (1), was isolated from the fermentation broth of bacterial strain 530603, which was identified as a new Paenibacillus species based on morphological and physiological characteristics, and 16S rRNA sequences. KB425796-A (1) was isolated as white powder by solvent extraction, HP-20 and ODS-B column chromatography, and lyophilization, and was determined to have the molecular formula C79H115N19O18. KB425796-A (1) showed antifungal activities against Aspergillus fumigatus and the micafungin-resistant infectious fungi Trichosporon asahii, Rhizopus oryzae, Pseudallescheria boydii and Cryptococcus neoformans.
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Kai, H., Yamashita, M., Takase, S. et al. KB425796-A, a novel antifungal antibiotic produced by Paenibacillus sp. 530603. J Antibiot 66, 465–471 (2013). https://doi.org/10.1038/ja.2013.63
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DOI: https://doi.org/10.1038/ja.2013.63
