Abstract
Furbenicillin is a broad-spectrum semisynthetic penicillin with strong antibacterial activity against Gram-negative bacteria. In this study, three impurities in furbenicillin, including an unknown epimer, were determined. On the basis of a complete analysis of the spectrum (MS, 1H,13C, 2D NMR and CD) and the results of chemical methods, the unknown epimer impurity was identified as 10-epi-furbenicillin (impurity 1). Isolation and structure elucidation of impurity 1 was also reported here for the first time.
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This study was supported by Youth development research foundation of NIFDC (2013NA2).
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Tian, Y., Chang, Y., Feng, YC. et al. Isolation, identification and characterization of related substances in furbenicillin. J Antibiot 68, 133–136 (2015). https://doi.org/10.1038/ja.2014.145
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DOI: https://doi.org/10.1038/ja.2014.145
