Abstract
A novel abrogator of bleomycin-induced G2 arrest in Jurkat cells, habiterpenol (1), was isolated from the culture broth of Phytohabitans suffuscus 3787_5. The planar structure of 1 was elucidated by spectroscopic study (1D and 2D NMR, MS, UV and IR), and the relative stereochemistry was elucidated by ROESY experiments. Compound 1 belongs to a pentacyclic meroterpenoid having a labdan-type diterpene connecting to an indane moiety.
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References
Uchida, R. et alHabiterpenol, a novel abrogator of bleomycin-induced G2 arrest in Jurkat cells, produced by Phytohabitans suffuscus 3787_5. J. Antibiot. 67, 777–781 (2014).
Sabry, O. M. et al. Neurotoxic meroditerpenoids from the tropical marine brown alga Stypopodium flabelliforme. J. Nat. Prod. 68, 1022–1030 (2005).
Abatis, D. et al. Atomarianones A and B: two cytotoxic meroditerpenes from the brown alga Taonia atomaria. Tetrahedron Lett. 46, 8525–8529 (2005).
Penicooke, N. et al. Antiproliferative activity and absolute configuration of zonaquinone acetate from the Jamaican alga Stypopodium zonale. Phytochemistry 87, 96–101 (2013).
Acknowledgements
We express our thanks to Ms N Sato and Dr K Nagai, School of Pharmacy, Kitasato University, for measurements of NMR and mass spectra.
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Uchida, R., Yokota, S. & Tomoda, H. Structure elucidation of meroterpenoid habiterpenol, a novel abrogator of bleomycin-induced G2 arrest in Jurkat cells, produced by Phytohabitans suffuscus 3787_5. J Antibiot 67, 783–786 (2014). https://doi.org/10.1038/ja.2014.71
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DOI: https://doi.org/10.1038/ja.2014.71
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