Abstract
A new (2) and four known (1, 8–10) sesquiterpenoids, two new (3 and 4) and eight known (5–7, 11–15) xanthone derivatives were isolated from the cultures of sponge-derived fungus Stachybotry sp. HH1 ZDDS1F1-2. The structure of the compounds 1–15 was determined mainly by analysis of the one-dimensional and two-dimensional NMR spectroscopic data and by analogy with the data of those reported. Compound 1 was confirmed by X-ray crystallography. All the compounds were tested for their cytotoxic, antiinflammatory and antiviral (EV71) effects. Compounds 5, 7 and 11 showed significant cytotoxicity against selected human tumor cell lines. Compounds 3, 4 and 11 also displayed significant inhibitory activity against cycloooxygenase (COX-2). Compounds 4, 5 and 11 showed activities against intestinal virus EV71.
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Acknowledgements
This work was supported financially by the National Key Basic Research Program of China (973)’s Project (2010CB833800 and 2011CB915503), the 863 Program (2012AA092104 and 2013AA092902), the National Natural Science Foundation of China (Nos. 52102308, 31270402, 21172230, 20902094, 41176148, 21002110, 31270402, 21172094 and 41376155), Guangdong Province-CAS Joint Research Program (2011B090300023 and 2012B091100264), and Guangdong Marine Economic Development and Innovation of Regional Demonstration Project (GD2012-D01-001 and GD2012-D01-002).
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Qin, C., Lin, X., Lu, X. et al. Sesquiterpenoids and xanthones derivatives produced by sponge-derived fungus Stachybotry sp. HH1 ZSDS1F1-2. J Antibiot 68, 121–125 (2015). https://doi.org/10.1038/ja.2014.97
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DOI: https://doi.org/10.1038/ja.2014.97
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