Abstract
A new cytotoxic viriditoxin derivative, cladosporinone (1), along with the known viriditoxin (2) and two viriditoxin derivatives (3 and 4) were obtained from the fungus C ladosporium cladosporioides isolated from the sediment of a hypersaline lake in Egypt. The structure of the new compound (1) was determined by 1D and 2D NMR measurements as well as by high-resolution ESIMS and electronic circular dichroism spectroscopy. All isolated compounds were studied for their cytotoxicity against the murine lymphoma cell line L5187Y and for their antibiotic activity against several pathogenic bacteria. Viriditoxin (2) was the most active compound in both bioassays. Compound 1 also exhibited strong cytotoxicity against the murine lymphoma cell line L5187Y with an IC50 value of 0.88 μm, whereas its antibiotic activity was weak.
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Acknowledgements
The financial support by the German Federal Ministry of Education and Support (BMBF; Bundesministerium für Bildung und Forschung) granted to PP and by the Ministry of Science and Technology (MOST) to WHL are gratefully acknowledged. YL wishes to thank the China Scholarship Council and the Ministry of Education of China for awarding her with a scholarship. The authors are indebted to Prof. MS Abdel-Aziz (National Research Center, Egypt) for his help during the collection of sediment from the hypersaline lake El Hamra in Egypt and to Prof. H Brötz-Oesterhelt (University of Tuebingen, Germany) for performing the antibacterial assays.
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Liu, Y., Kurtán, T., Yun Wang, C. et al. Cladosporinone, a new viriditoxin derivative from the hypersaline lake derived fungus Cladosporium cladosporioides. J Antibiot 69, 702–706 (2016). https://doi.org/10.1038/ja.2016.11
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DOI: https://doi.org/10.1038/ja.2016.11
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