Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
References
Zhang, J. et al. Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase. Microb. Cell Fact. 14, 152–163 (2015).
Burg, R. W. et al. Avermectins, new family of potent anthelmintic agents: isolation and chromatographic properties. Antimicrob. Agents Chemother. 15, 368–371 (1979).
Campbell, W. C. et al. Ivermectin: a potent new antiparasitic agent. Science 221, 823–828 (1983).
Elgart, G. W. & Meinking, T. L. Ivermectin. Dermatol. Clin. 21, 277–282 (2003).
Shen, B. A new golden age of natural products drug discovery. Cell 163, 1297–1300 (2015).
Lim, L. E. et al. Anthelmintic avermectins kill Mycobacterium tuberculosis, including multidrug-resistant clinical strains. Antimicrob. Agents Chemother. 57, 1040–1046 (2013).
Pouliot, J. F., L’Heureux, F., Prichard, R. K. & Georges, E. Reversal of P-glycoprotein-associated multidrug resistance by ivermectin. Biochem. Pharmacol. 53, 17–25 (1997).
Gao, A. L. et al. Reversal of P-glycoprotein-mediated multidrug resistance. J. Pharm. Pharmacol. 62, 393–399 (2010).
Xiang, W. S. et al. Reversal of P-glycoprotein-mediated multidrug resistance in vitro by milbemycin compounds in adriamycin-resistant human breast carcinoma (MCF-7adr) cells. Toxicol. In Vitro 24, 1474–1481 (2010).
Wang, H. Y. et al. Combined application of plasma mutagenesis and gene engineering leads to 5-oxomilbemycins A3/A4 as main components from Streptomyces bingchenggensis. Appl. Microbiol. Biotechnol. 98, 9703–9712 (2014).
Yoshihiro, O. et al Milbemycins manufacture with Streptomyces and by chemical synthesis. JP6345768 (1994).
Naito, S., Owatari, Y. & Saito, A. Regeneration of the milbemycin's C2-C4 structural arrangement from Δ2-milbemycin. Tetrahedron Lett. 35, 7797–7800 (1994).
Takiguchi, Y., Mishima, H., Okuda, M. & Terao, M. Milbemycins, a new family of macrolide antibiotics: fermentation, isolation and physico-chemical properties. J. Antibiot. 33, 1120–1127 (1980).
Hoye, T. R., Jeffrey, C. S. & Shao, F. Mosher ester analysis for the determination of absolute configuration of stereogenic (chiral) carbinol carbons. Nat. Protoc. 2, 2451–2458 (2007).
Huang, J. et al. Gene replacement for the generation of designed novel avermectin derivatives with enhanced acaricidal and nematicidal activities. Appl. Environ. Microbiol. 81, 5326–5334 (2015).
Pan, J. J. et al. Three new milbemycins from a genetically engineered strain S. avermitilis MHJ1011. J. Antibiot. 69, 104–107 (2016).
Acknowledgements
This research was financially supported by grants from the National Outstanding Youth Foundation (No. 31225024), the National Natural Science Foundation of China (No. 31471832, 31171913, 31500010, 31572070 and 31372006), the National Key Technology R&D Program (No. 2012BAD19B06) and Chang Jiang Scholar Candidates Program for Provincial Universities in Heilongjiang (CSCP).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Rights and permissions
About this article
Cite this article
Li, J., Zhang, S., Zhang, H. et al. Isolation and identification of new macrocyclic lactones from a genetically engineered strain Streptomyces bingchenggensis BCJ60. J Antibiot 70, 297–300 (2017). https://doi.org/10.1038/ja.2016.130
Received:
Revised:
Accepted:
Published:
Issue date:
DOI: https://doi.org/10.1038/ja.2016.130
This article is cited by
-
Cistobislactones A-B, two sixteen-membered spiro-linked macrocylic bislactones from marine octopus Cistopus indicus: new anti-inflammatory agents attenuate arachidonate 5-lipoxygenase
Medicinal Chemistry Research (2021)
-
Recent advances in the research of milbemycin biosynthesis and regulation as well as strategies for strain improvement
Archives of Microbiology (2021)
-
Two New 5-Oxomilbemycins Possessing an Unusual 3,27-Epoxy Bond from the Genetically Engineered Strain Streptomyces bingchenggensis BCJ60
Chemistry of Natural Compounds (2021)