Abstract
Five new pteridic acids C–G (1–5) were isolated from a culture broth of the marine-derived actinomycete Streptomyces sp. SCSGAA 0027. Their complete structures were elucidated on the basis of NMR data, modified Mosher’s method and quantum chemical calculations. Furthermore, their cytotoxicity, antiviral and antimicrobial activities were also evaluated.
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Acknowledgements
We are grateful for the financial support provided by the National Natural Science Foundation of China (41376160 and 81673326), National Natural Science Foundation of China (41606100), Strategic Leading Special Science and Technology Program of Chinese Academy of Sciences (XDA100304002), Natural Science Foundation of Guangdong Province, China (2015A030310349) and Regional Innovation Demonstration Project of Guangdong Province Marine Economic Development (GD2012-D01-002). We appreciate the contribution of the analytical facility center (Xiao Zhihui, Li Chuanrong, Sun Aijun and Zhang Yun) of South China Sea Institute of Oceanology, Chinese Academy of Sciences for acquiring NMR, HRESIMS and experimental CD data. We are also grateful for the support given by the Guangzhou Branch of the Supercomputing Center of Chinese Academy of Sciences.
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Nong, XH., Wei, XY. & Qi, SH. Pteridic acids C–G spirocyclic polyketides from the marine-derived Streptomyces sp. SCSGAA 0027. J Antibiot 70, 1047–1052 (2017). https://doi.org/10.1038/ja.2017.105
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DOI: https://doi.org/10.1038/ja.2017.105
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