Abstract
A new eremophilane sesquiterpene, 13,13-dimethoxyintegric acid (1), together with known compound integric acid (2) have been isolated from a fungus, Xylaria sp. V-27, obtained from a dead branch. The structure of 1 was established by means of spectroscopic analyses. 1 and 2 promoted growth restoring activity against the mutant yeast strain (Saccharomyces cerevisiae (zds1Δ erg3Δ pdr1Δ pdr3Δ)) and inhibited degranulation of rat basophilic leukemia RBL-2H3 cells stimulated by immnunoglobulin G + 2,4-dinitrophenylated-bovine serum albumin (IgE+DNP-BSA), thapsigargin and A23187.
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AT acknowledges the JSPS RONPAKU (dissertation PhD, ID: R11516) Program for financial support.
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Tchoukoua, A., Suzuki, T., Ariefta, N. et al. A new eremophilane sesquiterpene from the fungus Xylaria sp. V-27 and inhibition activity against degranulation in RBL-2H3 cells. J Antibiot 70, 1129–1132 (2017). https://doi.org/10.1038/ja.2017.120
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DOI: https://doi.org/10.1038/ja.2017.120
