Abstract
Four new 12,8-Eudesmanolides (1−4) and one known compound 5 named 13-Hydroxy-3,7(11)-eudesmadien-12,8-olide, were isolated from a mangrove rhizosphere-derived fungus Eutypella sp. 1–15. Their structures with absolute stereochemistry were determined by the comprehensive spectroscopic data, experimental and calculated ECD analysis. Compound 1 exhibited potent anticancer activity against JEKO-1 and HepG2 with IC50 values of 8.4 and 28.5 μM, respectively. Additionally, compound 1 also showed moderate antimicrobial activity.
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Acknowledgements
This work was supported by grants from the National Natural Science Foundation of China (No 81422045, U1405223 and 81661138005), the Fundamental Research Funds for the Central Universities of China (No 20720160064 and 20720160031), and Xiamen Southern Oceanographic Center (14GYY002NF02).
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Wang, Y., Wang, Y., Wu, Aa. et al. New 12,8-Eudesmanolides from Eutypella sp. 1–15. J Antibiot 70, 1029–1032 (2017). https://doi.org/10.1038/ja.2017.89
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DOI: https://doi.org/10.1038/ja.2017.89
