Abstract
Selections on human mitochondrial variations are difficult to examine. In this study, we found possible signs of selection on mitochondrial M7 lineages among the Gelong people who migrated from Guizhou to Hainan (the hottest province in China) throughout the last 1000 years. The genetic structure of the Gelong people shows an obvious sex-biased population admixture pattern with only 4.9% paternal contribution but 30.7% maternal contribution from indigenous Hlai people. According to frequency spectrum tests for deviation from neutrality and mismatch tests of demographic expansion, part of the maternal mitochondrial M7 lineages among the Gelong came from the Hlai had spread quickly and therefore might have undergone positive selection. In the future, whole mitochondrial genome sequencing might reveal the functional advantage of the M7 lineages.
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Acknowledgements
We thank all of those who donated samples. Our research was supported by the National Natural Science Foundation of China (30860124, 30890034, 31071098), Natural Science Foundation of Hainan (061014), Natural Science Foundation of Shanghai (10ZR1402200), Shanghai Committee of Education Research Innovation Key Project (11zz04), National Outstanding Youth Science Foundation of China (30625016), Shanghai Leading Academic Discipline Project and the Genographic project.
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The Genographic Consortium: Syama Adhikarla1, Christina J Adler2, Elena Balanovska3, Oleg Balanovsky3, Doron M Behar4, Jaume Bertranpetit5, Andrew C Clarke6, David Comas5, Alan Cooper2, Clio SI Der Sarkissian2, Matthew C Dulik7, Christoff J Erasmus8, Jill B Gaieski7, ArunKumar GaneshPrasad1, Wolfgang Haak2, Angela Hobbs8, Asif Javed9, Matthew E Kaplan10, Begoña MartÃnez-Cruz5, Elizabeth A Matisoo-Smith6, Marta Melé5, Nirav C Merchant10, R John Mitchell11, Amanda C Owings7, Laxmi Parida9, Ramasamy Pitchappan1, Daniel E Platt9, Lluis Quintana-Murci12, Colin Renfrew13, Daniela R Lacerda14, Ajay K Royyuru9, FabrÃcio R Santos14, Theodore G Schurr7, Himla Soodyall8, David F Soria Hernanz15, Pandikumar Swamikrishnan16, Chris Tyler-Smith17, Kavitha Valampuri John1, Arun Varatharajan Santhakumari1, Pedro Paulo Vieira18, Janet S Ziegle19 and R Spencer Wells15
Affiliations for participants: 1Madurai Kamaraj University, Madurai, Tamil Nadu, India. 2University of Adelaide, South Australia, Australia. 3Research Centre for Medical Genetics, Russian Academy of Medical Sciences, Moscow, Russia. 4Rambam Medical Center, Haifa, Israel. 5Universitat Pompeu Fabra, Barcelona, Spain. 6University of Otago, Dunedin, New Zealand. 7University of Pennsylvania, Philadelphia, PA, USA. 8National Health Laboratory Service, Johannesburg, South Africa. 9IBM, Yorktown Heights, NY, USA. 10University of Arizona, Tucson, AZ, USA. 11La Trobe University, Melbourne, Victoria, Australia. 12Institut Pasteur, Paris, France. 13University of Cambridge, Cambridge, UK. 14Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. 15National Geographic Society, Washington, DC, USA. 16IBM, Somers, NY, USA. 17The Wellcome Trust Sanger Institute, Hinxton, UK. 18Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. 19Applied Biosystems, Foster City, CA, USA.
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Yang, K., Zheng, H., Qin, Z. et al. Positive selection on mitochondrial M7 lineages among the Gelong people in Hainan. J Hum Genet 56, 253–256 (2011). https://doi.org/10.1038/jhg.2010.165
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DOI: https://doi.org/10.1038/jhg.2010.165
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