Abstract
We previously performed a survey of the sperm characteristics of the partners of pregnant women in four cities in Japan. In the present study, we analyzed the sperm characteristics of these subjects and the correlations between these sperm characteristics and climatic changes or Y chromosome haplogroups. Our results showed that more haplogroup D2a1 males than O2b1 males were born in the first half of the year (January to June), whereas more O2b1 males were born in the last half of the year (July to December) (P<0.05). This was agreed and correlated with the seasonal variations in their mean sperm concentrations. The haplogroup C, D* and D2a1 males displayed lower sperm concentrations from March to May, followed by an increase in their sperm concentrations starting in June or July, while the O2b1 males displayed higher sperm concentrations in the first half of the year followed by a sudden decrease from July to August (P<0.05). We hypothesize that the Japanese climate has different effects on the sperm characteristics and reproductive seasonality of males from different lineages; and therefore, has influenced the modern population of Japan.
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References
Karafet, T. M., Mendez, F. L., Meilerman, M. B., Underhill, P. A., Zegura, S. L. & Hammer, M. F. New binary polymorphisms reshape and increase resolution of the human Y chromosomal haplogroup tree. Genome. Res. 18, 830–838 (2008).
Zhong, H., Shi, H., Qi, X. B., Xiao, C. J., Jin, L., Ma, R. Z. et al. Global distribution of Y-chromosome haplogroup C reveals the prehistoric migration routes of African exodus and early settlement in East Asia. J. Hum. Genet. 55, 428–435 (2010).
Hammer, M. F. & Horai, S. Y chromosomal DNA variation and the peopling of Japan. Am. J. Hum. Genet. 56, 951–962 (1995).
Tajima, A., Hayami, M., Tokunaga, K., Juji, T., Matsuo, M., Marzuki, S. et al. Genetic origins of the Ainu inferred from combined DNA analyses of maternal and paternal lineages. J. Hum. Genet. 49, 187–193 (2004).
Hammer, M. F., Karafet, T. M., Park, H., Omoto, K., Harihara, S., Stoneking, M. et al. Dual origins of the Japanese: common ground for hunter-gatherer and farmer Y chromosomes. J. Hum. Genet. 51, 47–58 (2006).
Wen, B., Li, H., Lu, D., Song, X., Zhang, F., He, Y. et al. Genetic evidence supports demic diffusion of Han culture. Nature 431, 302–305 (2004).
Jin, H. J., Kwak, K. D., Hammer, M. F., Nakahori, Y., Shinka, T., Lee, J. W. et al. Y-chromosomal DNA haplogroups and their implications for the dual origins of the Koreans. Hum. Genet. 114, 27–35 (2003).
Nakagome, Y., Young, S. R., Akane, A., Numabe, H., Jin, D. K., Yamori, Y. et al. A Y-associated allele may be characteristic of certain ethnic groups in Asia. Ann. Hum. Genet. 56, 311–314 (1992).
Lin, S. J., Tanaka, K., Leonard, W., Gerelsaikhan, T., Dashnyam, B., Nyamkhishig, S. et al. A Y-associated allele is shared among a few ethnic groups of Asia. Jpn. J. Hum. Genet. 39, 299–304 (1994).
Kuroki, Y., Iwamoto, T., Lee, J., Yoshiike, M., Nozawa, S., Nishida, T. et al. Spermatogenic ability is different among males in different Y chromosome lineage. J. Hum. Genet. 44, 289–292 (1999).
Krausz, C., Quintana-Murci, L., Rajpert-De, Meyts, E., Jørgensen, N., Jobling, M. A. et al. Identification of a Y chromosome haplogroup associated with reduced sperm counts. Hum. Mol. Genet. 10, 1873–1877 (2001).
Baba, K., Nishida, T., Yoshiike, M., Nozawa, S., Hoshino, T. & Iwamoto, T. Current status of reproductive function in Japanese fertile men: international collaborative project on a study of partners of pregnant women. Int. J. Androl. 23(Suppl 2) 54–56 (2000).
Jørgensen, N., Andersen, A. G., Eustache, F., Irvine, D., Suominen, J. S. S., Petersen, J. H. et al. Regional differences in semen quality in Europe. Hum. Reprod. 16, 1012–1019 (2001).
Iwamoto, T., Nozawa, S., Yoshiike, M., Hoshino, T., Baba, K., Matsushita, T. et al. Semen quality of 324 fertile Japanese men. Hum. Reprod. 21, 760–765 (2006).
Su, B., Xiao, C., Deka, R., Seielstad, M. T., Kangwanpong, D., Xiao, J. et al. Y chromosome haplotypes reveal prehistorical migrations to the Himalayas. Hum. Genet. 107, 582–590 (2000).
Underhill, P. A., Passarino, G., Lin, A. A., Shen, P., Mirazon, Lahr, M. et al. The phylogeography of Y chromosome binary haplotypes and the origins of modern human populations. Ann. Hum. Genet. 65, 43–62 (2001).
de Carvalho, C. M., Zuccherato, L. W., Fujisawa, M., Shirakawa, T., Riberio-dos-Santos, A. K., Santos, S. E. et al. Study of AZFc partial deletion gr/gr in fertile and infertile Japanese males. J. Hum. Genet. 51, 794–799 (2006).
Excoffier, L. & Lischer, H. E. Arlequin suite ver 3.5: a new series of programs to perform population genetics analyses under Linux and Windows. Mol. Ecol. Resour. 10, 564–567 (2010).
Miura, T. The influence of seasonal atmospheric factors on human reproduction. Experimentia 43, 48–54 (1987).
Janett, F., Thun, R., Niederer, K., Burger, D. & Hässig, M. Seasonal changes in semen quality and freezability in the warmblood stallion. Theriogenology 60, 453–461 (2003).
Levine, R. J., Bordson, B. L., Mathew, R. M., Brown, M. H., Stanley, J. M. & Star, T. B. Deterioration of semen quality during summer in New Orleans. Fertil. Steril. 49, 900–907 (1988).
Politoff, L., Birkhauser, M., Almendral, A. & Zorn, A. New data confirming a circannual rhythm in spermatogenesis. Fertil. Steril. 52, 486–489 (1989).
Snyder, P. J. Fewer sperm in the summer—it’s not the heat, it’s…. N. Engl. J. Med. 323, 54–56 (1990).
Levine, R. J., Brown, M. H., Bell, M., Shue, F., Greenberg, G. N. & Bordson, B. L. Air-conditioned environments do not prevent deterioration of human semen quality during the summer. Fertil. Steril. 57, 1075–1083 (1992).
Li, Y., Lin, H., Ma, M., Li, L., Cai, M., Zhou, N. et al. Semen quality of 1346 healthy men, results from the Chongqing area of southwest China. Hum. Reprod. 24, 459–469 (2009).
Zou, Z., Hu, H., Song, M., Shen, Y., Guo, X., McElreavey, K. et al. Semen quality analysis of military personnel from six geographical areas of People’s Republic of China. Fertil. Steril. 95, 2018–2023 (2011).
Ma, K., Sharkey, A., Kirsch, S., Vogt, P., Keil, R., Hargreave, T. B. et al. Towards the molecular localization of the AZF locus: mapping of microdeletions in azoospermic men within 14 subintervals of interval 6 of the human Y chromosome. Hum. Mol. Genet 1, 29–33 (1992).
Vogt, P., Chandley, A. C., Hargreave, T. B., Keil, R., Ma, K. & Sharkey, A. Microdeletions in interval 6 of the Y chromosome of males with idiopathic sterility point to disruption of AZF, a human spermatogenesis gene. Hum. Genet. 89, 491–496 (1992).
Sin, H. S., Koh, E., Shigehara, K., Sugimoto, K., Maeda, Y., Yoshida, A. et al. Features of constitutive gr/gr deletion in a Japanese population. Hum. Reprod. 25, 2396–2403 (2010).
Acknowledgements
This study was supported by the Ministry of Health and Welfare of Japan (1013201) and the European Union (BMH4-CT96-0314). We thank all the volunteers who participated in this study. We are grateful to Miss Yukiko Unemi, Keiko Tsuji and Mr Kensuke Sasaki for their excellent technical assistance.
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Nakahori, Y., Sato, Y., Ewis, A. et al. Climatic influence on the reproductive characteristics of Japanese males. J Hum Genet 57, 375–378 (2012). https://doi.org/10.1038/jhg.2012.38
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DOI: https://doi.org/10.1038/jhg.2012.38
