Table 1 TNF-α, IL-6 and IL-17A levels in plasma and portal vein in mice subjected to sham operation, unilateral (UNx) or bilateral (BNx) nephrectomy or renal ischemia and reperfusion (RIR)

Systemic plasma	TNF-α (pg/ml)	IL-6 (pg/ml)	IL-17A (pg/ml)
Sham 24 h	3.4±1.5 (4)	88.2±32.6 (4)	0.0±0.0 (4)
UNx 5 h	20.5±2.9 (4)^*	430.3±37.9 (4)^*	103.7±12.0 (4)^*
UNx 24 h	58.9±12.7 (4)^*	573.1±55.6 (4)^*	171.7±15.4 (4)^*
BNx 5 h	373.4±9.3 (8)^*	3751.1±866.9 (7)^*	192.4±48.4 (4)^*
BNx 24 h	497.1±121.7 (4)^*	15926±2203.6 (4)^*	294.6±60.3 (4)^*
RIR (20 min) 5 h	21.8±1.5 (4)^*	2302±366.4 (4)^*	98.8±10.0 (4)^*
RIR (20 min) 24 h	114.0±32.2 (6)^*	4483.4±1295.3 (6)^*	176.2±26.1 (4)^*
RIR (30 min) 5 h	404.9±32.1 (4)^*	1160.5±211.0 (4)^*	128.6±9.5 (4)^*
RIR (30 min) 24 h	513.2±33.1 (4)^*	1720.9±345.7 (4)^*	421.0±42.5 (4)^*
IgG Ab BNx 24 h	453.1±33.0 (4)^*	11131.7±1783.1 (4)^*	238.9±17.9 (4)^*
TNF-α Ab BNx 24 h	15.7±15.7 (4)⁺	781.2±215.7 (4)^*⁺	42.1±29.5 (4)⁺
IL-6 Ab BNx 24 h	73.2±10.5 (4)^*⁺	897.6±389.5 (4)^*⁺	71.3±24.6 (4)^*⁺
IL-17A Ab BNx 24 h	14.0±5.1 (4)^*⁺	844.6±96.7 (4)^*⁺	69.6±42.6 (4)⁺
IgG Ab RIR (20 min) 24 h	136.8±18.4 (4)^*	4497.2±290.6 (4)^*	155.7±17.2 (3)^*
TNF-α Ab RIR (20 min) 24 h	15.9±10.0 (4)⁺	555.9±112.7 (4)^*⁺	61.9±13.6 (3)^*⁺
IL-6 Ab RIR (20 min) 24 h	36.7±24.8 (4)^*⁺	167.1±167.1 (4)⁺	85.0±14.1 (3)^*⁺
IL-17A Ab RIR (20 min) 24 h	42.6±8.9 (3)^*⁺	1027.7±61.5 (3)^*⁺	15.5±1.3 (3)^*⁺
Portal vein plasma	(pg/ml)	(pg/ml)	(pg/ml)
Sham 5 h	36.8±16.9 (4)	0.0±0.0 (4)	47.7±27.5 (4)
BNx 5 h	256.0±34.9 (4)^*^#	212.9±20.0 (4)^*^#	472.5±85.2 (4)^*^#
RIR (30 min) 5 h	295.9±19.8 (4)^*^#	317.4±45.5 (4)^*^#	510.8±37.1 (4)^*^#

Ab, antibody; IgG Ab, IgG isotype control antibody; TNF-α, tumor necrosis factor alpha; IL-6, interleukin 6; IL-17A, interleukin 17A.
The data are presented as mean±s.e.m. ^*P<0.05 vs sham-operated mice; ⁺P<0.05 vs IgG-Ab-treated mice; ^#P<0.05 vs systemic plasma.

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