Table 3 Systemic plasma alanine aminotransferase (ALT) and creatinine (Cr) levels in mice subjected to sham operation, bilateral nephrectomy (BNx) or 30 min renal ischemia reperfusion (RIR)
From: Cytokines induce small intestine and liver injury after renal ischemia or nephrectomy
ALT (U/L) | Cr (mg/dl) | ||||
---|---|---|---|---|---|
5 h | 24 h | 5 h | 24 h | ||
C57 | Sham | 53±6 (4) | 61±8 (4) | 0.48±0.02 (4) | 0.50±0.03 (4) |
C57 (WT) | BNx | 221±9 (8)* | 132±18 (6)* | 1.22±0.04 (8)* | 2.68±0.13 (6)* |
TNF-α KO | BNx | 134±11 (4)*# | ND | 1.51±0.10 (4)* | ND |
IL-6 KO | BNx | 82±4 (4)*# | ND | 1.17±0.04 (4)* | ND |
IL-17A KO | BNx | 103±15 (7)*# | 128±15 (4)* | 1.31±0.03 (7)* | 2.45±0.04 (4)* |
IL-17R KO | BNx | 76±3 (4)*# | ND | 1.13±0.05 (4)* | ND |
C57 (WT) | RIR | 170±12 (8)* | 238±18 (8)* | 1.13±0.05 (8)* | 2.36±0.06 (8)* |
TNF-α KO | RIR | 95±6 (4)*# | 83±10 (4)# | 0.68±0.04 (4)# | 1.07±0.02 (4)*# |
IL-6 KO | RIR | 90±6 (4)*# | ND | 0.51±0.04 (4)# | ND |
IL-17A KO | RIR | 104±8 (6)*# | 89±8 (4)# | 0.66±0.04 (6)# | 1.06±0.08 (4)*# |
IL-17R KO | RIR | 90±6 (4)*# | ND | 0.54±0.04 (4)# | ND |
IgG Ab | BNx | 423±105 (4)* | 463±83 (4)* | 1.23±0.06 (4)* | 2.37±0.12 (4)* |
TNF-α Ab | BNx | 74±10 (4)+ | 93±9 (4)*+ | 0.93±0.05 (4)* | 1.91±0.08 (4)* |
IL-6 Ab | BNx | 87±8 (4)*+ | 104±5 (4)*+ | 0.93±0.07 (4)* | 2.00±0.16 (4)* |
IL-17A Ab | BNx | 91±25 (4)*+ | 96±5 (4)*+ | 1.19±0.03 (4)* | 2.12±0.19 (4)* |
IgG Ab | RIR | 412±28 (4)* | 319±28 (4)* | 1.15±0.05 (4)* | 2.37±0.06 (4)* |
TNF-α Ab | RIR | 207±25 (4)*+ | 243±7 (4)*+ | 0.55±0.06 (4)+ | 0.90±0.05 (4)*+ |
IL-6 Ab | RIR | 217±35 (4)*+ | 222±20 (4)* | 0.68±0.04 (4)*+ | 0.99±0.13 (4)*+ |
IL-17A Ab | RIR | 93±8 (4)*+ | 78±6 (4)*+ | 0.61±0.04 (4)*+ | 1.15±0.06 (4)*+ |
IgG Ab | HIR | 10296±793 (6)* | 10887±503 (6)* | 0.65±0.05 (6)* | 0.97±0.05 (6)* |
TNF-α Ab | HIR | 9133±1668 (4)* | 4703±1040 (4)*+ | 0.71±0.04 (4)* | 0.69±0.04 (4)*+ |
IL-6 Ab | HIR | 10155±2173 (4)* | 3680±236 (4)*+ | 0.73±0.06 (4)* | 0.77±0.03 (4)*+ |
IL-17A Ab | HIR | ND | 2726±305 (4)*+ | ND | 0.72±0.04 (4)*+ |
IgG Ab | BNx+HIR | 14649±837 (6)*$ | 15021±2074 (6)*$ | 2.02±0.07 (6)*$ | 2.65±0.20 (6)*$ |
TNF-α Ab | BNx+HIR | 6202±1579 (4)*+ | 6066±623 (4)*+ | 1.80±0.17 (4)* | 2.70±0.08 (4)* |
IL-6 Ab | BNx+HIR | 6407±1754 (4)*+ | 5384±582 (4)*+ | 1.81±0.36 (4)* | 2.57±0.20 (4)* |
IL-17A Ab | BNx+HIR | ND | 4007±1142 (4)*+ | ND | 2.99±0.11 (4)* |
IgG Ab | RIR+HIR | 21346±2742 (4)*$ | 17311±1689 (4)*$ | 1.24±0.08 (4)*$ | 2.15±0.06 (4)*$ |
TNF-α Ab | RIR+HIR | 12361±1196 (7)*+ | 9542±906 (7)*+ | 0.66±0.02 (7)*+ | 1.20±0.15 (7)*+ |
IL-6 Ab | RIR+HIR | 12237±1318 (6)*+ | 10212±1309 (6)*+ | 0.84±0.05 (6)*+ | 1.32±0.16 (6)*+ |
IL-17A Ab | RIR+HIR | ND | 2331±996 (4)*+ | ND | 1.28±0.16 (4)*+ |