Figure 5
From: High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy
Intraperitoneal injection of HMGB1 increased MCP-1 expression and worsened kidney function in rats with DHA crystal-induced nephritis. HMGB1 injection aggravated renal failure with increased BUN (a) and serum creatinine (b) in DHA crystal-induced nephritis rats. (c) Significant MCP-1 increase in serum was detected at 4 and 5 weeks. Adenine-fed rats were compared with the HMGB1 injection and saline injection groups. Each data point represents the mean±s.d. for three rats; *P<0.05, **P<0.01: saline-injected rats vs HMGB1-injected rats in DHA crystal-induced nephritis rats.
