Figure 6
From: High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy
Histological changes of kidneys in WT and Hmgb1+/− mice with DHA crystal-induced nephritis. The color change to yellow of the kidneys was more profound in WT adenine mice compared with Hmgb1+/− adenine mice. In histological observation, the basophilic areas that indicate inflammatory cell infiltration (arrows) were more remarkable in the kidney tissues of WT adenine mice compared with those of Hmgb1+/− adenine mice. The renal tissues of both control groups were intact. H.E. staining; Original magnifications: × 25.
