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Novel non-TCR chromosome translocations t(3;11)(q25;p13) and t(X;11)(q25;p13) activating LMO2 by juxtaposition with MBNL1 and STAG2

Leukemia volume 25, pages 1632–1635 (2011)Cite this article

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The 26 T-ALL cell lines analyzed in this study (http://www.dsmz.de) are listed in Supplementary Table 1. LMO2 rearrangements were identified in 5/26 (19.2%) cell lines. These comprised t(11;14)(p13;q11.2) in TALL-104, where the partner gene is TR@D confirming an earlier report,2 and an additional four cell lines which tested positive for non-TCR alterations, namely: del(11)(p13p13) in P12/ICHIKAWA, t(3;11)(q25;p13) in MOLT-16 and t(X;11)(q25;p13) in MOLT-14 and PER-117. Both t(3;11) and t(X;11) are described in this study for the first time and represent a new class of rearrangement with distal 5′-LMO2 breakpoints.

FISH revealed an altogether different kind of LMO2 rearrangement in MOLT-16, t(3;11)(q25;p13) which cryptically exchanges similar sized and banded regions (Figure 2b). The 11p13 breakpoint lies ∼155 Kbp upstream of LMO2. FISH placed the 3q25 breakpoint near the promoter region of the muscleblind-like protein 1 (MBNL1) gene (Figure 1) ubiquitously expressed in hematopoietic cells and hitherto known for the toxic sequestration of its protein to RNA repeats in myotonic dystrophy.

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Authors and Affiliations

  1. DSMZ - German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany

    S Chen, S Nagel, B Schneider, M Kaufmann, C Meyer, M Zaborski, H G Drexler & R A F MacLeod

  2. Jiangsu Institute of Hematology, First Affiliated Hospital. Soochow University, Suzhou, People's Republic of China

    S Chen

  3. Telethon Institute for Child Health Research, University of Western Australia, Perth, Australia

    U R Kees

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  1. S Chen
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Correspondence to R A F MacLeod.

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Chen, S., Nagel, S., Schneider, B. et al. Novel non-TCR chromosome translocations t(3;11)(q25;p13) and t(X;11)(q25;p13) activating LMO2 by juxtaposition with MBNL1 and STAG2. Leukemia 25, 1632–1635 (2011). https://doi.org/10.1038/leu.2011.119

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