Figure 4
S1PR1 blockade reduces KLRG1-CD4 T cells in the lung vasculature. (a) Representative FACS plots of lung I-Ab:ESAT-64-17 tetramer+ CD4 T cells from H56/CAF01-vaccinated (lower plots) and adjuvant control (upper plots) C57BL/6 mice infected for 7 weeks with Mtb followed by 48 hr treatment with (right) or without (left) FTY720. (b) Bar graph shows the proportion of KLRG1– of I-Ab:ESAT-64-17 tetramer+ CD4 T cells in the lung vasculature (IV+) for each treatment group. Bar, mean±s.e.m. of n=3 mice per group. *P<0.05.
