Table 3 Pathogenesis of UIP

From: Smoking-related interstitial fibrosis (SRIF), pathogenesis and treatment of usual interstitial pneumonia (UIP), and transbronchial biopsy in UIP

I

Primary Inflammation—Early Theory

 

Alveolitis → Fibrosis

Cytokines/other substances

II

Primary Injury—Current Theory

 

Epithelial injury → Fibroblast foci → Fibrosis

(Inflammation/Cytokines)

Abnormal wound healing