Table 2 General immunohistochemical features helpful in resolving the differential diagnosis of urinary bladder glandular malignancies
Cadherin-17 | GATA3 (nuclear) | β-Catenin | p63 | |
|---|---|---|---|---|
Primary urinary bladder adenocarcinoma | Positive | Negative | Usually membranous | Negative |
Urothelial carcinoma with glandular differentiation | Negative | Sometimes positive (urothelial>glandular) | Usually membranous for both urothelial and glandular components | Urothelial carcinoma component, usually positive; glandular component, negative |
Secondary involvement of bladder by colorectal adenocarcinoma | Positive | Negative | Usually nuclear | Negative |
Primary colorectal adenocarcinoma | Positive | Negative | Usually nuclear | Negative |
