Figure 4 | Modern Pathology

Figure 4

From: Expression status of wild-type HSP110 correlates with HSP110 T17 deletion size and patient prognosis in microsatellite-unstable colorectal cancer

Figure 4

Kaplan–Meier survival analysis with the log-rank test demonstrates the prognostic significance of HSP110wt expression in MSI-H colorectal cancers. (a) There are significant survival differences among the four groups, according to the HSP110wt immunohistochemistry scores of all MSI-H colorectal cancer patients (n=168; P=0.036). (b) Patients with low expression of HSP110wt (0/1+) show better disease-free survivals than do the high expression group (2+/3+) from all patients with MSI-H colorectal cancer (n=168; P=0.005). (c, d) The low expression group (0/1+) is also associated with better disease-free survival in 5-FU-based chemotherapy-treated (c, n=108) or AJCC TNM stage III/IV (d, n=60) subgroups of MSI-H colorectal cancer patients (P=0.024 and P=0.032, respectively).

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