Table 1 Clinicopathological and molecular characteristics according to the HSP110wt expression status in MSI-H colorectal cancers (n=168)
Characteristics | Case no. | Low expression of HSP110wt (0/1+) | High expression of HSP110wt (2+/3+) | P-value |
|---|---|---|---|---|
Clinicopathological factors | ||||
Age | ||||
<59 years | 85 | 23 (58%) | 62 (48%) | 0.317 |
≥59 years | 83 | 17 (43%) | 66 (52%) | |
Gender | ||||
M | 89 | 19 (48%) | 70 (55%) | 0.427 |
F | 79 | 21 (53%) | 58 (45%) | |
Tumor location | ||||
Right sided | 113 | 30 (75%) | 83 (65%) | 0.232 |
Left sided | 55 | 10 (25%) | 45 (35%) | |
Tumor multiplicity | ||||
Solitary | 147 | 34 (85%) | 113 (88%) | 0.584 |
Multiple | 21 | 6 (15%) | 15 (12%) | |
Gross tumor type | ||||
Polypoid | 25 | 6 (15%) | 19 (15%) | 0.981 |
Ulcerative | 143 | 34 (85%) | 109 (85%) | |
AJCC TNM stage | ||||
Stage I/II | 108 | 27 (68%) | 81 (63%) | 0.627 |
Stage III/IV | 60 | 13 (33%) | 47 (37%) | |
Tumor differentiation | ||||
WD/MD | 128 | 33 (83%) | 95 (74%) | 0.283 |
PD | 40 | 7 (18%) | 33 (26%) | |
Mucinous histology | ||||
Absent | 74 | 17 (43%) | 57 (45%) | 0.821 |
Present | 94 | 23 (58%) | 71 (55%) | |
Medullary carcinoma component | ||||
Absent | 162 | 38 (95%) | 124 (97%) | 0.629 |
Present | 6 | 2 (5%) | 4 (3%) | |
Signet ring cell carcinoma component | ||||
Absent | 157 | 35 (88%) | 122 (95%) | 0.134 |
Present | 11 | 5 (13%) | 6 (5%) | |
Molecular factors | ||||
MLH1 expression | ||||
Loss | 105 | 27 (68%) | 78 (61%) | 0.454 |
Retained | 63 | 13 (33%) | 50 (39%) | |
MSH2 expression | ||||
Loss | 55 | 15 (38%) | 40 (31%) | 0.462 |
Retained | 113 | 25 (63%) | 88 (69%) | |
PMS2 expression | ||||
Loss | 111 | 28 (70%) | 83 (65%) | 0.548 |
Retained | 57 | 12 (30%) | 45 (35%) | |
MSH6 expression | ||||
Loss | 59 | 16 (40%) | 43 (34%) | 0.459 |
Retained | 109 | 24 (60%) | 85 (66%) | |
CIMP | ||||
CIMP-H | 41 | 4 (10%) | 37 (29%) | 0.015 |
CIMP-L/0 | 127 | 36 (90%) | 91 (71%) | |
KRAS mutation | ||||
Wild type | 130 | 33 (89%) | 97 (78%) | 0.12 |
Mutant | 32 | 4 (11%) | 28 (22%) | |
BRAF mutation | ||||
Wild type | 148 | 36 (92%) | 112 (88%) | 0.568 |
Mutant | 19 | 3 (8%) | 16 (13%) | |
HSP110 T 17 deletion size | ||||
3 bp or less | 77 | 3 (8%) | 74 (58%) | <0.001 |
4 bp or more | 90 | 36 (92%) | 54 (42%) | |
