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Population-based and family-based association studies of ZNF804A locus and schizophrenia

Molecular Psychiatry volume 16, pages 360–361 (2011)Cite this article

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Recently, O’Donovan et al.1 genome-wide association study found the single-nucleotide polymorphism rs1344706, in intron 2 of ZNF804A on chromosome 2q32.1, to be associated (P=1.61 × 10−7) with schizophrenia (MIM 181500).

Thus, ZNF804A is very likely a true susceptibility locus for schizophrenia, albeit one that confers a small increment in risk.1, 2 We examined rs1344706 within two independent samples of Han Chinese populations: a population-based sample and a family-based sample. Our results provide further evidence for a positive association between the ZNF804A locus and schizophrenia.

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Authors and Affiliations

  1. Department of Genetics and Molecular Biology, Xi’an Jiaotong University School of Medicine, Xi’an, Shaanxi, China

    R Zhang, S M Lu & J Ma

  2. Institute of Molecular Genetics, School of Life Science & Technology, Xi’an Jiaotong University, Xi’an, Shaanxi, China

    C Qiu, X G Liu & H W Deng

  3. Psychiatry Department, First Affiliated Hospital, Xi’an Jiaotong University School of Medicine, Xi’an, Shaanxi, China

    C G Gao

  4. The Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA

    T W Guo

  5. Department of Pediatrics, Arizona Health Science Center, University of Arizona, Tucson, AZ, USA

    R K Valenzuela

Authors
  1. R Zhang
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  2. S M Lu
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  3. C Qiu
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  4. X G Liu
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  5. C G Gao
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  6. T W Guo
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  7. R K Valenzuela
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  8. H W Deng
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  9. J Ma
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Corresponding authors

Correspondence to S M Lu or J Ma.

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Zhang, R., Lu, S., Qiu, C. et al. Population-based and family-based association studies of ZNF804A locus and schizophrenia. Mol Psychiatry 16, 360–361 (2011). https://doi.org/10.1038/mp.2010.55

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