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Goat genome sequence by optical mapping

Nature Biotechnology volume 31, page 123 (2013)Cite this article

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With the report from Dong et al.1 in this issue, the goat joins the pig, cow and chicken as major livestock species to have been sequenced. The authors assembled the genome de novo from short sequencing reads derived from a female Yunnan black goat.

A key limitation of genome sequencing using short reads is that the assembly usually consists of thousands of small fragments. Joining the fragments is a time-consuming, laborious process as it requires the generation of maps of markers throughout the genome. Dong et al.1 have simplified this step by taking advantage of a method known as optical mapping2. The goat genome represents the first application to a large, mammalian genome of a commercial optical mapping technology, which provides raw whole-genome mapping data in a matter of hours.

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References

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  1. H. Craig Mak, Associate Editor, Nature Biotechnology,

    H Craig Mak

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  1. H Craig Mak
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Mak, H. Goat genome sequence by optical mapping. Nat Biotechnol 31, 123 (2013). https://doi.org/10.1038/nbt.2502

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