Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Reply to Updating benchtop sequencing performance comparison

Nature Biotechnology volume 31, page 296 (2013)Cite this article

Subjects

Loman et al. reply:

We were pleased to see this useful update from Jünemann et al.1 to our article 'Performance comparison of benchtop sequencers'2. Progress in sequencing technologies is driving genomic research at an astonishing rate. More than 14 months have elapsed since we submitted our manuscript based on data generated in the summer of 2011. There have been impressive changes in throughput (up to fivefold) and read length (up to fourfold) during this time, easily outperforming Moore's Law. However, we note that despite these improvements, our overall conclusions on the relative performance of the 454 GS Junior, Ion Torrent Personal Genome Machine (PGM) and Illumina MiSeq benchtop sequencers remain unchanged.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Jünemann, S. et al. Nat. Biotechnol. 31, 294–295 (2013).

    Article  Google Scholar 

  2. Loman, N.J. et al. Nat. Biotechnol. 30, 434–439 (2012).

    Article  CAS  Google Scholar 

  3. Quail, M.A. et al. BMC Genomics 13, 341 (2012).

    Article  CAS  Google Scholar 

  4. Liu, L. et al. J. Biomed. Biotechnol. 2012, 251364 (2012).

    PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University of Birmingham, Birmingham, UK

    Mark John Pallen

Authors
  1. Mark John Pallen
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Mark John Pallen.

Ethics declarations

Competing interests

M.J.P. was a winner of an Ion Torrent Personal Genome Machine in the European PGM grant program in 2011. N.J.L. has had expenses paid to speak at an Ion Torrent meeting organized by Life Technologies and has received honoraria and expenses to speak at Illumina meetings. Both authors have collaborated with staff in Illumina R&D.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pallen, M. Reply to Updating benchtop sequencing performance comparison. Nat Biotechnol 31, 296 (2013). https://doi.org/10.1038/nbt.2531

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nbt.2531

This article is cited by

Search

Advanced search

Quick links

Nature Briefing Microbiology

Sign up for the Nature Briefing: Microbiology newsletter — what matters in microbiology research, free to your inbox weekly.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing: Microbiology