Supplementary Figure 11: Two-dimensional colored heatmap of the T cell subnetwork pulled from the IP map.

Data organized by drug (rows) and T cell categories (columns). Predicted interactions between drug categories (ATC level 1 categories: H = Systemic hormonal preparations, excl. sex hormones and insulins, B = Blood and blood forming organs, V = Various, L = Anti-neoplastic and immunomodulating agents, P = Anti-parasitic products, M = Musculo-skeletal system, G = Genito urinary system and sex hormones, R = Respiratory system, S = Sensory organs, D = Dermatologicals, A = Alimentary tract and metabolism, N = Nervous system, J = Anti-infectives for systemic use, and C = Cardiovascular system) and (left) T cell subsets “Cell Types” or (right) identical T cell subset found in different tissues. All connections are statistically significant (P < 0.05 and FDR < 5%, see methods). Each colored cell in the heatmap represents the fraction of drugs from a particular ATC level 1 category (0–0.7, max = 1.0) predicted to influence the specific Cell Type or Tissue location. Colored circles represent the number of drugs in each category where the size is proportional to the number of unique drugs (16–144).