Supplementary Figure 13: Influence of guanfacine on regulatory T cells. | Nature Biotechnology

Supplementary Figure 13: Influence of guanfacine on regulatory T cells.

From: Mapping the effects of drugs on the immune system

Supplementary Figure 13

(a) Graph showing connections for a single drug, Guanfacine, predicted to influence regulatory T cells based on the immunemod score (shown as numbers next to each node). (b) Percentage of regulatory T cells (CD4+FoxP3+CD62L+) isolated from mouse spleens following treatment with the anti-hypertensive drug guanfacine. Each circle is a separate mouse from five separate experiments—grouped by color—for a total of 14 or 15 mice in the Ctrl and Guanfacine groups respectively. Dashed lines connect the mean frequency values between groups in each experiment. Significance assessed by meta analysis (see below).

Morgan, A.A., Khatri, P., Jones, R.H., Sarwal, M.M. & Butte, A.J. Comparison of multiplex meta analysis techniques for understanding the acute rejection of solid organ transplants. BMC Bioinformatics 11 Suppl 9, S6 (2010).

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