Supplementary Figure 4: Schematic depiction of our method to test for significant interactions and identify robust connections.

(a) Diagram of ranked list comparison to calculate the immunemod score for each pair of drug (j) and cell state change (k) at a particular gene set size (l). (b) Gene set size variation procedure to evaluate the robustness of each predicted interaction. (c) Schematic of the permutation testing to assess the significance of an immunemod score for a given drug (j), cell state change (k), and gene set size (l).