Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

A systems approach to HIV-1 vaccines

Understanding the full breadth of immune responses that protect against HIV-1 may speed vaccine development.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: An integrated serological profiling approach reported by Chung et al.1 for identification of unique humoral Fc-related vaccine signatures (left) compared to other approaches (right).

Katie Vicari/Nature Publishing Group

References

  1. Chung, A.W. et al. Cell 163, 988–998 (2015).

    Article  CAS  Google Scholar 

  2. Shibata, R. et al. Nat. Med. 5, 204–210 (1999).

    Article  CAS  Google Scholar 

  3. Caskey, M. et al. Nature 522, 487–491 (2015).

    Article  CAS  Google Scholar 

  4. Xiao, X. et al. Biochem. Biophys. Res. Commun. 390, 404–409 (2009).

    Article  CAS  Google Scholar 

  5. Dimitrov, D.S. MAbs 2, 347–356 (2010).

    Article  Google Scholar 

  6. Haynes, B.F., Kelsoe, G., Harrison, S.C. & Kepler, T.B. Nat. Biotechnol. 30, 423–433 (2012).

    Article  CAS  Google Scholar 

  7. Rerks-Ngarm, S. et al.; MOPH-TAVEG Investigators. N. Engl. J. Med. 361, 2209–2220 (2009).

    Article  CAS  Google Scholar 

  8. Haynes, B.F. et al. N. Engl. J. Med. 366, 1275–1286 (2012).

    Article  CAS  Google Scholar 

  9. Yates, N.L. et al. Sci. Transl. Med. 6, 228ra39 (2014).

    Article  Google Scholar 

  10. Chung, A.W.E. et al. Sci. Transl. Med. 6, 228ra38 (2014).

    Article  Google Scholar 

  11. Corey, L. et al. Sci. Transl. Med. 7, 310rv7 (2015).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Dimiter S Dimitrov.

Ethics declarations

Competing interests

Ponraj Prabakaran is a full-time employee of Intrexon Corporation.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ying, T., Prabakaran, P. & Dimitrov, D. A systems approach to HIV-1 vaccines. Nat Biotechnol 34, 44–46 (2016). https://doi.org/10.1038/nbt.3456

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nbt.3456

This article is cited by

Search

Quick links

Nature Briefing Microbiology

Sign up for the Nature Briefing: Microbiology newsletter — what matters in microbiology research, free to your inbox weekly.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing: Microbiology