After years under the radar, RNA vaccines are finally emerging as immunotherapies to combat pandemics and cancer. But as Laura DeFrancesco reports, clinical validation remains elusive.
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References
Hekele, A. et al. Emerg. Microbes Infect. 2, e52 (2013).
Tcherepanova, I.Y. et al. BMC Mol. Biol. 9, 9 (2008).
Wolff, J.A. et al. Science 247, 1465–1468 (1990).
Sahin, U., Karikó, K. & Türeci, Ö. Nat. Rev. Drug Discov. 13, 759–780 (2014).
Karikó, K., Buckstein, M., Ni, H. & Weissman, D. Immunity 23, 165–175 (2005).
Karikó, K. et al. Mol. Ther. 16, 1833–1840 (2008).
Warren, L. et al. Cell Stem Cell 7, 618–630 (2010).
Zhou, X. et al. Vaccine 12, 1510–1514 (1994).
Ricci, E.P. et al. Nat. Struct. Mol. Biol. 21, 26–35 (2014).
Santangelo, P.J. et al. Nat. Methods 12, 427–432 (2015).
Geall, A.J. et al. Proc. Natl. Acad. Sci. USA 109, 14604–14609 (2012).
Brito, L.A. et al. Mol. Ther. 22, 2118–2129 (2014).
Kranz, L.M. et al. Nature 534, 396–401 (2016).
Chahal, J.S. et al. Proc. Natl. Acad. Sci. USA 113, E4133–E4142 (2016).
Heiser, A. et al. J. Clin. Invest. 109, 409–417 (2002).
Motzer, R.J. et al. Br. J. Cancer 108, 2470–2477 (2013).
Weide, B. et al. J. Immunother. 32, 498–507 (2009).
Kübler, H. et al. J. Immunother. Cancer 3, 26 (2015).
Diken, M. et al. Methods Mol. Biol. 1499, 223–236 (2017).
Kreiter, S. et al. Nature 520, 692–696 (2015).
Pardi, N. et al. Nature http://dx.doi.org/10.1038/nature21428 (2017).
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DeFrancesco, L. The 'anti-hype' vaccine. Nat Biotechnol 35, 193–197 (2017). https://doi.org/10.1038/nbt.3812
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DOI: https://doi.org/10.1038/nbt.3812
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