Table 3 Recently announced job reductions in the biotech sector

From: Small-cap biotechs in dire straits

Company

Layoffs by number

Layoffs by percentageof workforce

Details

Cyclacel Pharmaceuticals

28

34%

Changes will lower annual costs by $9 million, with enough cash to fund operations until 2Q 2010

Dyax

60

36%

Restructuring will result in $18 million in annual savings

TorreyPines Therapeutics

10

70%

Follows the restructuring in March, the board subsequently voted to liquidate and dissolve the company. Subject to shareholder approval

Ziopharm Oncology

4

19%

Has enough cash to fund development of palifosfamide into 2Q 2010

Sunesis Pharmaceuticals

6

17%

Received a $10 million private placement in late March

Genaera

Undisclosed

80%

Board subsequently approved a plan to dissolve the company and liquidate its assets

BioXell

14

36%

On 12/31/2008, had €43.6 million ($61.4 million) in cash and a 12-month operating loss of €16.7 million.

ZymoGenetics

161

32%

Cuts will save about $30 million annually beginning in 3Q 2009

Sequenom

30

12%

Cuts will be in genetic analysis business unit

Discovery Laboratories

24

21%

On 3/31/2009, had $19.1 million in cash

Adherex Technologies

13

76%

Has sufficient cash for planned development and operational activities into September

Johnson & Johnson

900

6%

Cuts will come largely from sales force

Quidel

31

10%

On 12/31/2008, had $57.9 million in cash and a 12-month operating profit of $28.6 million

Vermillion

Undisclosed

Undisclosed

Filed for Chapter 11 bankruptcy

Amylin Pharmaceuticals

200

35%

Will combine its existing primary care and specialty sales forces into a single organization

Cell Genesys

Undisclosed

Undisclosed

Eliminated all R&D, manufacturing, clinical and regulatory activities; expects further reductions during the next few months as additional activities are phased out or outsourced

Evotec

45

12%

Cuts will come from the consolidation of its European facilities and the wind down of operations at its USsubsidiary Renovis

MannKind

100

17%

On 3/31/2009, had $30.2 million in cash and a three-month operating loss of $57.8 million

Neurocrine Biosciences

60

50%

On 3/31/2009, had $66.4 million in cash and a three-month operating loss of $19.1 million

Progenics Pharmaceuticals

25

10%

On 3/31/2009, had $127.7 million in cash and a three-month operating loss of $2.6 million

Alizyme

2

15%

On 12/31/2008, had £2.2 million) ($3.2 million in cash and a 12-month operating loss of £11.7 million($17 million)

Adolor

45

28%

Cuts are expected to save about $12 million annually

Anadys Pharmaceuticals

Undisclosed

40%

Will also relocate to a smaller facility to reduce costs and focus on ANA598

Thallion Pharmaceuticals

12

27%

Expects the cuts to reduce its annual cash burn by about CAD$1 million ($888,600) and will allow the company to operate into 2011

  1. Source: BioCentury.