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Cofactor-mediated protein promiscuity

Nature Biotechnology volume 27, page 892 (2009)Cite this article

To the Editor:

The review article by Nobeli et al.1 in the February issue creates a conceptual framework for protein binding and functional promiscuity and delineates its significance for biotech. As the interpretation of protein promiscuity in the literature is itself promiscuous, this timely review comes to clarify important features of this phenomenon. The authors have proposed a comprehensive classification of the mechanisms responsible for protein recognition and functional promiscuity. We believe, however, that an important additional mechanism for protein promiscuity could be added to this classification.

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Acknowledgements

Our work was supported by Howard Hughes Medical Institute grant 55000340.

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Authors and Affiliations

  1. INSERM U872, Centre de Recherche des Cordeliers, Université Pierre et Marie Curie - Paris, Paris, France

    Jordan D Dimitrov

  2. Stefan Angelov Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria

    Tchavdar L Vassilev

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  1. Jordan D Dimitrov
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  2. Tchavdar L Vassilev
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Correspondence to Jordan D Dimitrov or Tchavdar L Vassilev.

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Dimitrov, J., Vassilev, T. Cofactor-mediated protein promiscuity. Nat Biotechnol 27, 892 (2009). https://doi.org/10.1038/nbt1009-892a

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