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Collective nomenclature for LAP proteins

Nature Cell Biology volume 2, page E114 (2000)Cite this article

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In 1996 Mary Kennedy and colleagues isolated the protein Densin-180 from the rbat postsynaptic density1. This protein had a unique structure, in that it contained a set of leucine-rich repeats (LRRs) as well as a PSD-95/Dlg/ZO-1 (PDZ) domain; these domains are thought to mediate protein–protein interactions. Recently, further proteins containing both types of domain have been isolated from fly2, worm3, mouse4 and human4,5. It seems an opportune time to select a collective name for this family of proteins.

We endorse the name ‘LAP (LRR And PDZ domain) proteins’ for proteins with this structure. We emphasize that the individual proteins will not be renamed. The known LAP proteins contain 16 canonical LRRs located at the amino terminus of the protein, as well as a conserved, LRR-like region immediately carboxy-terminal to the LRRs. The LRRs from LAP proteins are more closely related to each other than to LRRs from other proteins. The known LAP proteins also contain either one or four PDZ domains. It may be useful to distinguish between these subfamilies by using the designations ‘LAP1’ and ‘LAP4’ respectively.

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Figure 1: The LAP protein family.

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GenBank/EMBL/DDBJ

References

  1. Apperson et al. J. Neurosci. 16, 6389–6352 (1996).

  2. Bilder, D. & Perrimon, N. Nature 403, 676–680 (2000).

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Authors and Affiliations

  1. Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA

    David Bilder & Norbert Perrimon

  2. U119 INSERM, Molecular Oncology, Marseille, France

    Daniel Birnbaum & Jean-Paul Borg

  3. Developmental Biology Center, University of California at Irvine, California, USA

    Peter Bryant

  4. ICMB, University of Texas at Austin, Texas, USA

    Jon Huigbretse

  5. Laboratory for Molecular Oncology, CME, University of Leuven and VIB, Leuven, Belgium

    Erik Jansen & Marleen Petit

  6. Division of Biology, California Institute of Technology, Pasadena, California, USA

    Mary B. Kennedy

  7. IGBMC, CNRS/INSERM/ULP, Illkirch, France

    Michel Labouesse & Renaud Legouis

  8. Developmental Genetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Bernard Mechler

  9. Drosophila Stock Center, University of Indore, India

    Pradip Sinha

Authors
  1. David Bilder
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  2. Daniel Birnbaum
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  3. Jean-Paul Borg
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  4. Peter Bryant
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  5. Jon Huigbretse
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  6. Erik Jansen
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  7. Mary B. Kennedy
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  8. Michel Labouesse
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  9. Renaud Legouis
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  10. Bernard Mechler
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  11. Norbert Perrimon
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  12. Marleen Petit
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  13. Pradip Sinha
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Bilder, D., Birnbaum, D., Borg, JP. et al. Collective nomenclature for LAP proteins. Nat Cell Biol 2, E114 (2000). https://doi.org/10.1038/35017119

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