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Tranexamic acid and uremic bleeding: evidence-based treatment recommendations

Nature Clinical Practice Nephrology volume 3, page E2 (2007)Cite this article

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Arising from: Hedges SJ et al. (2007) Evidence-based treatment recommendations for uremic bleeding. Nat Clin Pract Nephrol 3: 138–153 doi:10.1038/ncpneph0421

Author's response: Hedges SJ et al. (2007) Tranexamic acid and uremic bleeding: evidence-based treatment recommendations. Nat Clin Pract Nephrol [doi:10.1038/ncpneph0529]

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References

  1. Mezzano D et al. (1996) Hemostatic disorder of uremia: the platelet defect, main determinant of the prolonged bleeding time, is correlated with indices of activation of coagulation and fibrinolysis. Thromb Haemost 76: 312–321

    Article  CAS  Google Scholar 

  2. Mezzano D et al. (2001) Inflammation, not hyperhomocysteinemia, is related to oxidative stress and hemostatic and endothelial dysfunction in uremia. Kidney Int 60: 1844–1850

    Article  CAS  Google Scholar 

  3. Mezzano D et al. (1999) Tranexamic acid inhibits fibrinolysis, shortens the bleeding time and improves platelet function in patients with chronic renal failure. Thromb Haemost 82: 1250–1254

    Article  CAS  Google Scholar 

  4. Mezzano D et al. (2000) Fast decrease of bleeding time by tranexamic acid in uremia. Thromb Haemost 83: 785

    Article  CAS  Google Scholar 

  5. Vujkovac B et al. (1998) Successful treatment of bleeding from colonic angiodysplasias with tranexamic acid in a hemodialysis patient. Am J Kidney Dis 31: 536–538

    Article  CAS  Google Scholar 

  6. Vujkovac B and Sabovic M (2000) Treatment of subdural and intracerebral haematoma in a haemodialysis patient with tranexamic acid. Nephrol Dial Transplant 15: 107–109

    Article  CAS  Google Scholar 

  7. Sabovic M et al. (2003) Tranexamic acid is beneficial as adjunctive therapy in treating major upper gastrointestinal bleeding in dialysis patients. Nephrol Dial Transplant 18: 1388–1391

    Article  CAS  Google Scholar 

  8. Sabovic M et al. (2005) The effect of long term, low-dose tranexamic acid treatment on platelet dysfunction and haemoglobin levels in haemodialysis patients. Thromb Haemost 94: 1245–1250

    Article  CAS  Google Scholar 

  9. Vujkovac B and Sabovic M (2006) A successful treatment of life-threatening bleeding from polycystic kidneys with antifibrinolytic agent tranexamic acid. Blood Coagul Fibrinolysis 17: 589–591

    Article  Google Scholar 

  10. Mannucci PM et al. (1983) Deamino-8-D-arginine vasopressin shortens the bleeding time in uremia. N Engl J Med 308: 8–12

    Article  CAS  Google Scholar 

  11. Alarcón F et al. (1985) Effect of 1-deamino-8-D-arginine vasopressin (DDAVP) on bleeding time of uremic patients. Rev Med Chile 113: 763–768

    PubMed  Google Scholar 

  12. Rodgers RP and Levin J (1990) A critical reappraisal of the bleeding time. Semin Thromb Hemost 16: 1–20

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. in the Department of Nephrology, P Downey is Auxiliary Professor and R Tagle is Associate Instructor, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.,

    Patricio Downey & Rodrigo Tagle

  2. in the Department of Hematology–Oncology, J Pereira is Adjunct Professor and D Mezzano is Professor, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.,

    Jaime Pereira & Diego Mezzano

Authors
  1. Patricio Downey
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  2. Rodrigo Tagle
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  3. Jaime Pereira
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  4. Diego Mezzano
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Corresponding author

Correspondence to Diego Mezzano.

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The authors declare no competing financial interests.

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Downey, P., Tagle, R., Pereira, J. et al. Tranexamic acid and uremic bleeding: evidence-based treatment recommendations. Nat Rev Nephrol 3, E2 (2007). https://doi.org/10.1038/ncpneph0528

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